尿酸与脑梗死发病及预后相关性的研究进展

Progress in the association between uric acid and ischemic stroke

尿酸是嘌呤代谢的产物。既往研究发现,尿酸与脑梗死发病密切相关;另一方面,尿酸是人体主要的内源性抗氧化剂,可能可以减轻脑梗死患者氧化应激损伤,部分研究认为在脑梗死急性期外源性输注尿酸能改善患者预后。目前尿酸与脑梗死发病及预后的相关性尚存争议,深入了解尿酸与脑梗死发病及预后的关系,探索可能的作用机制,进而采取针对性预防和治疗措施,对脑梗死的防治有重要意义。

Uric acid(UA)is the end product of purine nucleotide metabolism.Previous studies found that UA was associated with ischemic stroke.On the other hand,UA is the major endogenous antioxidant,which may reduce oxidative stress in ischemic stroke patients.Some studies suggested that UA therapy during acute phase of ischemic stroke could improve patients’outcome.However,the association between UA and ischemic stroke and its prognosis remains unclear.Investigating the above association and its underlying mechanisms is of great clinical significance,which may help clinicians to make appropriate treatment and prevention measures.