胰腺神经内分泌肿瘤CT征象与组织学分级的关系

Relationship between CT signs and histological grade of pancreatic neuroendocrine neoplasm

目的探讨胰腺神经内分泌肿瘤(PNEN)CT征象与组织学分级的关系。方法选取29例PNEN患者,均接受CT扫描,依据WHO组织学分级分为G_(1)级13例,G_(2)级13例,G_(3)级3例,分析PNEN患者CT征象与组织学分级的关系。结果不同组织学分级PNEN患者病灶边缘、囊变或坏死情况、周围组织侵犯或转移情况、包膜破坏情况及淋巴结肿大情况等CT征象比较,差异均有统计学意义(P﹤0.05);不同组织学分级PNEN患者病灶部位、肿瘤形态、肿瘤直径及钙化情况等CT征象均无明显差异。组织学分级为G_(1)级的PNEN患者的CT绝对强化值、CT相对强化值均高于G_(2)级和G_(3)级患者(P﹤0.05),组织学分级为G_(2)级的PNEN患者的CT绝对强化值、CT相对强化值均高于G_(3)级患者(P﹤0.05)。结论CT可有效显示PNEN的影像学特征,不同组织学分级PNEN患者的CT征象有一定特性,可为临床早期PNEN的治疗提供可靠的依据。

Objective To explore the relationship between CT signs and histological grade of pancreatic neuroendocrine neoplasm(PNEN).Method Twenty-nine PNEN patients were selected and received CT scans.According to the WHO histological grade,they were divided into 13 cases of G_(1) grade,13 cases of G_(2) grade,and 3 cases of G_(3) grade.Analyze the relationship between CT signs and histological grade in PNEN patients.Result Comparison of CT signs such as lesion edge,cystic degeneration or necrosis,invasion or transfer of surrounding tissues,damaged capsule and lymphadenopathy in different histological grade of PNEN patients(P<0.05).There were no significant differences in CT signs such as lesion location,tumor shape,tumor diameter,and calcification in patients with different histological grade of PNEN(P>0.05).The absolute CT enhancement and relative CT enhancement values of PNEN patients with histological grade G_(1) were higher than those of patients with G_(2) and G_(3) grade(P<0.05),the absolute CT enhancement values and relative CT enhancement values of PNEN patients with histological grade G_(2) were higher than those of patients with G_(3) grade patients(P<0.05).Conclusion CT can effectively display the imaging characteristics of PNEN,and the CT signs of PNEN with different histological grades have certain characteristics,which can provide a reliable basis for the treatment of early clinical PNEN.