艾司西酞普兰联合乌灵胶囊治疗脑梗死恢复期合并抑郁临床研究

Clinical Study of Escitalopram Combined with Wuling Capsule in the Treatment of Cerebral Infarction with Depression during Recovery Period

目的探讨艾司西酞普兰联合乌灵胶囊在脑梗死恢复期合并抑郁中的应用效果。方法方便选取该院2019年4月—2020年4月期间共80例脑梗死恢复期合并抑郁患者,随机数表法设为对照组(n=40)以及观察组(n=40),分别开展常规艾司西酞普兰治疗以及艾司西酞普兰联合乌灵胶囊治疗。评价两组患者各项指标水平。结果治疗后,观察组患者HAMD分值(13.22±2.54)分低于对照组,差异有统计学意义(t=12.720,P<0.05);观察组治疗后IL-6(51.24±6.24)μg/L、IL-23(70.14±8.14)μg/L、TNF-α(75.25±8.24)μg/L、NE(80.87±9.01)ng/L、5-HT(296.32±33.46)μg/L低于对照组的(72.01±9.24)μg/L、(91.34±10.67)μg/L、(98.45±10.76)μg/L、(56.22±5.25)ng/L、(270.45±25.74)μg/L,差异有统计学意义(t=11.782、9.991、10.827、14.950、3.876,P<0.05)。结论对脑梗死恢复期合并抑郁患者开展艾司西酞普兰联合乌灵胶囊治疗,可有效改善患者心理状态以及炎症水平,对改善患者预后有积极意义。

Objective To explore the effect of escitalopram combined with Wuling capsule in the treatment of depression during the recovery period of cerebral infarction.Methods A total of 80 patients with cerebral infarction combined with depression during the recovery period of cerebral infarction were conveniently selected in the hospital from April 2019 to April 2020.The random number table method was set as the control group(n=40)and the observation group(n=40),and routine escitalopram was carried out for treatment,and escitalopram combined with Wuling capsule was carried out for treatment.Evaluate the levels of various indicators of the two groups of patients.Results After treatment,the HAMD score(13.22±2.54)points of the observation group was lower than that of the control group,the difference was statistically significant(t=12.720,P<0.05);IL-6(51.24±6.24)μg/L,IL-23(70.14±8.14)μg/L,TNF-α(75.25±8.24)μg/L,NE(80.87±9.01)ng/L,5-HT(296.32±33.46)μg/L in the observation group after treatment were lower than the control group(72.01±9.24)μg/L,(91.34±10.67)μg/L,(98.45±10.76)μg/L,(56.22±5.25)ng/L,(270.45±25.74)μg/L,the difference was statistically significant(t=11.782,9.991,10.827,14.950,3.876,P<0.05).Conclusion The treatment of escitalopram combined with Wuling capsules for patients with depression during recovery from cerebral infarction can effectively improve the mental state and inflammation level of the patients,and it has positive significance for improving the prognosis of the patients.