血清钙和凝血功能对急性胰腺炎严重程度和预后的效果评价

Evaluation of the Effect of Serum Calcium and Coagulation Function on the Severity and Prognosis of Acute Pancreatitis

目的探讨急性胰腺炎严重程度和预后效果与凝血功能和血清钙之间的关系。方法方便选取2019年1月—2020年6月在该院就诊的急性胰腺炎患者87例,依照随机数表法分为3组,各29例。A组为参照组,B组为轻症胰腺炎组,C组为重症胰腺炎组。对比血清钙水平、D-二聚体、凝血酶原时间、纤维蛋白原、活化部分凝血活酶时间。结果A组血清钙水平(2.45±0.06)pg/mL、B组血清钙水平(2.21±0.06)pg/mL、C组血清钙水平(1.86±0.05)pg/mL,相比于A组,B组、C组血清钙离子水平降低,差异有统计学意义(P<0.05);相比于A组,B组和C组D-D、APTT、PT、FPG水平明显较高,差异有统计学意义(P<0.05)。A组:PT(12.12±1.23)s、APTT(31.58±3.26)s、FPG(3.02±0.78)g/L、D-D(0.36±0.18)mg/L;B组:PT(12.96±1.35)s、APTT(34.35±6.21)s、FPG(3.65±1.21)g/L、D-D(0.62±0.38)mg/L;C组:PT(17.36±4.15)s、APTT(48.56±3.41)s、FPG(4.25±1.65)g/L、D-D(2.32±0.67)mg/L,差异有统计学意义(P<0.05)。结论急性胰腺炎的严重程度与血清钙水平和凝血功能存在一定关系,可作为疾病的判定和预后评估指标。

Objective To investigate the relationship between the severity and prognosis of acute pancreatitis,coagulation function and serum calcium.Methods From January 2019 to June 2020,87 patients with acute pancreatitis in the hospital were conveniently selected and divided into 3 groups according to the random number table method,with 29 cases in each group.Group A was the reference group,group B was the mild pancreatitis group,and group C was the severe pancreatitis group.Compared serum calcium level,D-dimer,prothrombin time,fibrinogen,activated partial thromboplastin time.Results The serum calcium level of group A(2.45±0.06)pg/mL,the serum calcium level of group B(2.21±0.06)pg/mL,the serum calcium level of group C(1.86±0.05)pg/mL.Compared with group A,the serum calcium ion levels of group B and group C were lower,and the difference between the groups was statistically significant(P<0.05);compared with group A,the levels of D-D,APTT,PT and FPG in group B and C were significantly higher,the difference between the groups was statistically significant(P<0.05).Group A:PT(12.12±1.23)s,APTT(31.58±3.26)s,FPG(3.02±0.78)g/L,D-D(0.36±0.18)mg/L;Group B:PT(12.96±1.35)s,APTT(34.35±6.21)s,FPG(3.65±1.21)g/L,D-D(0.62±0.38)mg/L;Group C:PT(17.36±4.15)s,APTT(48.56±3.41)s,FBG(4.25±1.65)g/L,D-D(2.32±0.67)mg/L,and the difference was statistically significant(P<0.05).Conclusion The severity of acute pancreatitis has a certain relationship with serum calcium level and blood coagulation function,which can be used as an index for disease judgment and prognosis evaluation.