Skull bone tumor:a review of clinicopathological and neuroimaging characteristics of 426 cases at a single center

Dear Editor,Among the wide array of human neoplasms,bone and soft tissue tumors originating from the skull bone are extremely rare,making up<2%of all the musculoskeletal tumors[1].Skull bone tumors exist as a distinct entity because they include multiple subtypes,have complex regional anatomical structure,and require interdiscipli-nary therapy.According to the 2002 world health organi-zation(WHO)histological typing[2],skull bone tumors can be divided into benign,malignant,and undefined neoplastic nature tumors(UNNTs).Given the lack of literatures systematically reporting this uncommon dis-order and the small-scale sample size published studies on these tumor entities[3,4],a deeper understanding of the clinicopathological features across skull bone tumor is necessary.We,therefore,conducted this retrospective analysis on bony tumor spectrum involving the primary and secondary lesions arising from the skull to document the various types of tumors encountered,and to analyze their epidemiological characteristics,clinicopathogical features and neuroradiographic parameters.