摘要
Background:The association between type 2 diabetes mellitus(T2DM)and the risk of esophageal cancer remains unclear.The present study aimed to evaluate the impact of T2DM on short-term outcomes and long-term survival in patients with esophageal squamous cell cancer(ESCC).Methods:The present retrospective study included 862 patients diagnosed with ESCC between January 2001 and December 2010.Among them,280 patients had T2DM.A 1:1 propensity score-matched cohort consisting of 280 patients with and 280 without T2DM was selected from the 862 patients.The associations between T2DM and clinico-pathologic characteristics were assessed using theχ2 or Fisher’s exact test.Survival of ESCC patients with and without T2DM was calculated by using the Kaplan-Meier method and compared by using the Cox regression model between the two groups.Results:The occurrence rate of anastomotic leakage was significantly higher in patients with T2DM than in those without T2DM(P<0.001).In the subgroup with weight loss rate≤5.05%,ESCC patients with T2DM had a signifi-cant longer overall survival than did those without T2DM(P=0.003),whereas in the subgroup with weight loss rate>5.05%,the patients without T2DM showed a longer survival(P=0.001).Univariate and multivariate analysis results showed that T2DM was not an independent prognostic factor for patient survival.Conclusions:Type 2 diabetes mellitus is not an independent prognostic factor in patients with ESCC.However,the combination of T2DM with severe weight loss would be a predictor of poor prognosis.
