摘要
Dysregulation of metabolism allows tumor cells to generate needed building blocks as well as to modulate epigenetic marks to support cancer initiation and progression.Cancer-induced metabolic changes alter the epigenetic landscape,especially modifications on histones and DNA,thereby promoting malignant transformation,adaptation to inadequate nutrition,and metastasis.Recent advances in cancer metabolism shed light on how aberrations in metabolites and metabolic enzymes modify epigenetic programs.The metabolism-induced recoding of epigenetics in cancer depends strongly on nutrient availability for tumor cells.In this review,we focus on metabolic remodeling of epigenetics in cancer and examine potential mechanisms by which cancer cells integrate nutritional inputs into epigenetic modification.
基金
supported by MOST(2015CB910401 to Q.-Y.L)
the Natural Science Foundation of China(81790253,81790250,and 81430057 to Q.-Y.L,81772946 and 81502379 to Y.-P.W.)
the Innovation Program of Shanghai Municipal Education Commission(N173606 to Q.-Y.L.)
the“Chenguang Program”of the Shanghai Education Development Foundation(14CG15 to Y.-P.W).
