盐酸贝那普利对原发性轻中度高血压患者心功能的影响

Effect of benazepril hydrochloride on cardiac function in patients with primary mild-to-moderate hypertension

目的研究盐酸贝那普利对原发性轻中度高血压患者心功能的影响。方法98例原发性轻中度高血压患者,随机分为对照组及研究组,各49例。对照组采用苯磺酸氨氯地平治疗,研究组采用盐酸贝那普利治疗。比较两组患者治疗前后的收缩压(SBP)、舒张压(DBP)、心率(HR)、心功能指标[舒张期末室间隔厚度(IVST)、左室后壁厚度(LVPWT)、左室舒张末期内径(LVEDD)、左心室重量指数(LVMI)]水平,不良反应发生情况。结果治疗后,研究组患者的SBP(130.33±10.17)mm Hg(1 mm Hg=0.133 kPa)、DBP(73.35±9.08)mm Hg、HR(70.03±5.87)次/min低于对照组的(142.15±11.34)mm Hg、(82.12±9.59)mm Hg、(73.36±6.05)次/min,差异具有统计学意义(P<0.05)。研究组患者的IVST(10.22±1.27)mm、LVPWT(10.42±1.32)mm、LVEDD(45.34±5.13)mm、LVMI(118.31±17.26)g/m^(2)小于对照组的(12.84±1.94)mm、(12.59±1.41)mm、(52.64±5.51)mm、(141.41±20.67)g/m^(2),差异具有统计学意义(P<0.05)。研究组患者的不良反应发生率为4.08%,与对照组的8.16%比较,差异无统计学意义(P>0.05)。结论盐酸贝那普利治疗原发性轻中度高血压的疗效理想,患者血压控制效果良好,可促进其心功能恢复,不易引发不良反应,可在临床治疗中推广使用,以期让原发性轻中度高血压患者更快恢复健康。

Objective To study the effect of benazepril hydrochloride on cardiac function in patients with primary mild-to-moderate hypertension.Methods A total of 98 patients with primary mild-to-moderate hypertension were randomly divided into control group and research group,with 49 cases in each group.The control group was treated with amlodipine besylate,and the research group was treated with benazepril hydrochloride.The systolic blood pressure(SBP),diastolic blood pressure(DBP),heart rate(HR),cardiac function indicators[inter-ventricular septal thickness(IVST),left ventricular posterior wall thickness(LVPWT),left ventricular end diastolic diameter(LVEDD),left ventricular mass index(LVMI)]before and after treatment,and occurrence of adverse reactions were compared between the two groups.Results After treatment,the SBP(130.33±10.17)mm Hg(1 mm Hg=0.133 kPa),DBP(73.35±9.08)mm Hg and HR(70.03±5.87)beats/min of the research group were lower than(142.15±11.34)mm Hg,(82.12±9.59)mm Hg and(73.36±6.05)beats/min of the control group,and the difference was statistically significant(P<0.05).The IVST(10.22±1.27)mm,LVPWT(10.42±1.32)mm,LVEDD(45.34±5.13)mm and LVMI(118.31±17.26)g/m^(2) of the research group were less than(12.84±1.94)mm,(12.59±1.41)mm,(52.64±5.51)mm and(141.41±20.67)g/m^(2) of the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions 4.08%of the research group had no statistically significant difference compared with 8.16%of the control group(P>0.05).Conclusion Benazepril hydrochloride has ideal efficacy on the treatment of primary mild-to-moderate hypertension.It can better control the blood pressure of patients,promote the recovery of heart function,and is not easy to cause adverse reactions.It can be promoted in clinical treatment to make patients recover faster.