试析WBC、CRP、PCT联合检测诊断新生儿早期细菌感染的临床意义

Clinical significance of combined detection of WBC,CRP and PCT in the diagnosis of neonatal early-onset bacterial infection

目的探究白细胞计数(WBC)、C反应蛋白(CRP)、降钙素原(PCT)联合检测诊断新生儿早期细菌感染的临床价值。方法选取17例局部细菌感染新生儿作为A组,同期23例重症细菌感染新生儿作为B组,同期40例健康新生儿作为健康参照组。三组均采集空腹肘静脉血检测WBC、CRP、PCT水平,并进行比较。结果A组、B组的WBC、CRP、PCT水平分别为(2.65±1.46)×10^(9)/L、(54.05±4.21)mg/L、(2.71±1.59)μg/L及(14.65±7.23)×10^(9)/L、(58.61±5.14)mg/L、(15.64±7.65)μg/L,均高于参照组的(0.23±0.05)×10^(9)/L、(4.70±1.10)mg/L、(0.20±0.04)μg/L,且B组高于A组,差异具有统计学意义(P<0.05)。结论在新生儿早期细菌感染诊断中应用WBC、CRP、PCT联合检测,可帮助医护人员了解新生儿的感染状况,并结合检测结果明确其病情,为下一步治疗工作的开展提供指导。

Objective To investigate the clinical value of combined detection of white blood cell count(WBC),C-reactive protein(CRP),procalcitonin(PCT)in the diagnosis of neonatal early-onset bacterial infection.Methods There were 17 neonates with local bacterial infection as group A,23 neonates with severe bacterial infection during the same period as group B,and 40 healthy neonates at the same period as healthy reference group.The fasting cubital venous blood was collected in the three groups to detect WBC,CRP and PCT levels and compare them.Results The WBC,CRP and PCT levels of group A and group B were(2.65±1.46)×10^(9)/L,(4.70±1.10)mg/L,(2.71±1.59)μg/L and(14.65±7.23)×10^(9)/L,(58.61±5.14)mg/L,(15.64±7.65)μg/L,which were higher than(0.23±0.05)×10^(9)/L,(4.70±1.10)mg/L and(0.20±0.04)μg/L of reference group,and group B was higher than group A.All the difference was statistically significant(P<0.05).Conclusion Combined detection of WBC,CRP,PCT in the diagnosis of neonatal early-onset bacterial infection can help medical staff to understand the infection status of the newborn,and combined with the detection results to determine the disease condition,and provide guidance for further treatment.