探索早期胰岛素强化降糖治疗对新发2型糖尿病非肥胖患者血浆促泌素表达水平的影响

Influence of early insulin intensive hypoglycemic therapy on the expression of plasma secretagogues in non-obese patients with newly-onset type 2 diabetes mellitus

目的探索早期胰岛素强化降糖治疗对新发2型糖尿病(T2DM)非肥胖患者血浆促泌素(SCGN)表达水平的影响。方法选取40例新发2型糖尿病非肥胖患者作为实验组,选取同期健康体检者40例为参照组。实验组患者采取早期胰岛素强化降糖治疗。比较两组治疗前后血浆SCGN水平。结果治疗前,实验组的血浆SCGN水平(898.5±144.5)pg/ml显著低于参照组的(1234.7±160.2)pg/ml,差异有统计学意义(t=9.856,P=0.000<0.05)。治疗后,实验组患者的血浆SCGN水平为(1150.5±158.4)pg/ml,低于参照组的(1234.7±160.2)pg/ml,差异有统计学意义(t=2.364,P=0.021<0.05)。但实验组治疗后的血浆SCGN水平高于治疗前,差异有统计学意义(P<0.05)。结论2型糖尿病非肥胖患者采用早期胰岛素强化治疗,可以提高血浆SCGN水平,同时,可以通过血浆SCGN水平对β细胞的损害情况进行评估。

Objective To discuss the influence of early insulin intensive hypoglycemic therapy on the expression of plasma secretagogues(SCGN)in non-obese patients with newly-onset type 2 diabetes mellitus(T2DM).Methods There were 40 cases of non-obese patients with newly-onset type 2 diabetes mellitus selected as the experimental group,and 40 healthy subjects as reference group.The experimental group was treated with early insulin intensive hypoglycemic therapy.The plasma SCGN before and after treatment were compared between the two groups.Results Before treatment,the plasma SCGN(898.5±144.5)pg/ml of the experimental group was significantly lower than(1234.7±160.2)pg/ml of the reference group,and the difference was statistically significant(t=9.856,P=0.000<0.05).After treatment,the plasma SCGN of the experimental group was(1150.5±158.4)pg/ml,which was lower than(1234.7±160.2)pg/ml of the reference group,and the difference was statistically significant(t=2.364,P=0.021<0.05).After treatment,the plasma SCGN of the experimental group was higher than that before treatment,and the difference was statistically significant(P<0.05).Conclusion Early insulin intensive hypoglycemic therapy can improve the plasma SCGN in non-obese patients with newly-onset type 2 diabetes mellitus,and the damage ofβ-cells can be assessed by plasma SCGN levels.