摘要
目的分析糖皮质激素应用于儿童腹型过敏性紫癜(HSP)中的最佳时机及效果。方法80例儿童腹型过敏性紫癜患儿,均采用糖皮质激素治疗,按治疗时机及方法的不同分为A组、B组、C组及D组,每组20例。A组实施早期糖皮质激素常规用药,B组实施晚期糖皮质激素常规用药,C组实施早期糖皮质激素快速滴定用药,D组实施晚期糖皮质激素快速滴定用药。比较四组患儿治疗后的各项临床指标、预后情况以及临床治疗效果。结果C组患儿症状缓解时间、激素使用时间短于A组、B组、D组,激素使用量低于A组、B组、D组,差异具有统计学意义(P<0.05)。C组患儿症状反复、消化道严重表现、紫癜性肾炎的发生率明显低于A组、B组、D组,差异具有统计学意义(P<0.05)。C组临床治疗总有效率为95.00%,明显高于A组的65.00%、B组的55.00%、D组的65.00%,差异有统计学意义(P<0.05)。结论采用早期快速滴定糖皮质激素治疗儿童腹型过敏性紫癜患儿,效果显著,能有效缓解患儿的临床症状,缩短患儿治疗时间,减少药物使用量,有助于促进患儿病情加快康复,值得应用。
Objective To analyze the best timing and effect of glucocorticoid in children with abdominal henoch-schonlein purpura(HSP).Methods A total of 80 children with abdominal henoch-schonlein purpura all were treated with glucocorticoids,and they were divided into group A,group B,group C and group D according to different treatment timing and methods,with 20 cases in each group.Group A was treated with early glucocorticoid routine medication,group B was treated with late glucocorticoid routine medication,group C was treated with early titration of glucocorticoid,and group D was treated with late titration of glucocorticoid.The clinical indicators,prognosis and clinical effect after treatment of the four groups were compared.Results The symptom remission time and hormone use time of group C were shorter than those of group A,group B and group D,and hormone use amount was lower than that of group A,group B and group D.All the difference was statistically significant(P<0.05).The incidence of recurrent symptoms,severe gastrointestinal manifestations,purpura nephritis of group C were obviously lower than those of group A,group B and group D,and the difference was statistically significant(P<0.05).The total effective rate of group C was 95.00%,which was obviously higher than 65.00%of group A,55.00%of group B and 65.00%of group D,and the difference was statistically significant(P<0.05).Conclusion Early titration of glucocorticoid has a significant effect on children with abdominal henoch-schonlein purpura,and it can effectively relieve the clinical symptoms of children,shorten the treatment time,reduce the drug use,and help to promote the recovery of children’s condition,which is worthy of application.
作者
夏毅如
陈振华
冯显富
XIA Yi-ru;CHEN Zhen-hua;FENG Xian-fu(Department of Pediatrics,Gaoming District People’s Hospital,Foshan 528500,China)
出处
《中国实用医药》
2021年第20期141-144,共4页
China Practical Medicine
关键词
糖皮质激素
儿童腹型过敏性紫癜
最佳时机
疗效
Glucocorticoid
Abdominal henoch-schonlein purpura in children
Best timing
Efficacy