摘要
Dear Editor,Esophageal cancer(EC)is the sixth leading cause of death from cancer worldwide[1].It has remained a large burden in the world,especially in China[2].Esophageal squamous cell carcinoma(ESCC)is the major histological subtype of EC and is mostly regarded as a‘silent’tumor in its early stage.Most patients are diagnosed at a late stage,due to a lack of symptoms in the early stages of the disease[3].Despite notable improvements in surgical techniques,adjuvant chemoradiotherapy,and screening with endoscopy using Lugol’s iodine staining,and nutritional intervention,ESCC still has the poorest prognosis among gastrointestinal cancers.The overall 5-year survival rate of patients with ESCC after radical esophagectomy remains below 30%[4].
基金
supported by grants from the National Key R&D Program of China(2017YFA0503900)
the National Natural Science Foundation of China(81772957)
the Science and Technology Program of Guangdong Province in China(2019B030301009)
the Industry and Information Technology Foundation of Shenzhen(20180309100135860).
