卡培他滨联合奥沙利铂治疗进展期老年胃癌的疗效及对患者IFN-γ、IL-2、TNF-β水平的影响分析

Efficacy of capecitabine combined with oxaliplatin in the treatment of advanced gastric cancer in the elderly and its influence of IFN-γ,IL-2 and TNF-β levels

目的探讨卡培他滨联合奥沙利铂治疗进展期老年胃癌的临床疗效及对患者γ-干扰素(IFN-γ)、白细胞介素-2(IL-2)、肿瘤坏死因子-β(TNF-β)水平的影响。方法70例老年胃癌患者,依据入院时间顺序分为对照组和观察组,各35例。对照组应用卡培他滨治疗,观察组应用卡培他滨联合奥沙利铂治疗。比较两组临床疗效、治疗后细胞因子相关指标、用药不良反应发生情况及治疗后生存质量。结果观察组治疗总有效率88.6%高于对照组的57.1%,差异具有统计学意义(P<0.05)。治疗前,两组IFN-γ、IL-2及TNF-β水平比较,差异无统计学意义(P>0.05);治疗后,两组IFN-γ、IL-2及TNF-β水平均高于治疗前,且观察组IFN-γ、IL-2及TNF-β水平均高于对照组,差异具有统计学意义(P<0.05)。观察组用药后不良反应发生率低于对照组,差异具有统计学意义(P<0.05)。观察组治疗后躯体功能、情绪状态、认知功能、角色功能、社会功能评分分别为(89.3±6.7)、(85.6±6.4)、(91.5±7.0)、(83.3±6.1)、(66.5±5.7)分,均高于对照组的(84.7±5.6)、(71.5±4.3)、(85.7±5.9)、(73.1±5.0)、(55.4±5.1)分,差异具有统计学意义(P<0.05)。结论卡培他滨联合奥沙利铂治疗进展期老年胃癌的临床疗效较为显著,有助于提升IFN-γ等细胞因子相关指标水平,减少用药不良反应发生几率,改善患者预后生存质量,值得进行推广应用。

Objective To discuss the clinical efficacy of capecitabine combined with oxaliplatin in the treatment of advanced gastric cancer in the elderly and its influence of interferon-γ(IFN-γ),interleukin-2(IL-2),tumor necrosis factor-β(TNF-β)levels.Methods A total of 70 elderly patients with gastric cancer were divided into control group and observation group according to admission order,with 35 cases in each group.The control group was treated with capecitabine,and the observation group was treated with capecitabine and oxaliplatin.The clinical efficacy,cytokine related indicators after treatment,occurrence of adverse drug reactions,and quality of life after treatment were compared between the two groups.Results The total effective rate 88.6%of the observation group was higher than 57.1%of the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in levels of IFN-γ,IL-2 and TNF-β between the two groups(P>0.05).After treatment,the levels of IFN-γ,IL-2 and TNF-β of the two groups were higher than those before treatment,and the observation group was higher than the control group.All the difference was statistically significant(P<0.05).The incidence of adverse reactions of the observation group after medication was lower than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the physical function,emotional state,cognitive function,role function,social function score of the observation group were(89.3±6.7),(85.6±6.4),(91.5±7.0),(83.3±6.1),(66.5±5.7)points,which were higher than(84.7±5.6),(71.5±4.3),(85.7±5.9),(73.1±5.0),(55.4±5.1)points of the control group,and the difference was statistically significant(P<0.05).Conclusion Combination of capecitabine and oxaliplatin has significant clinical effect in the treatment of advanced gastric cancer in the elderly,which can help to increase the level of IFN-γ and other cytokine-related indicators,reduce the incidence of adverse drug reactions,and improve the prognostic quality of life,which is worthy of promotion and application.