糖尿病前期患者糖代谢异常对慢性牙周炎的影响

Effect of abnormal glucose metabolism on chronic periodontitis in prediabetic patients

目的探究糖尿病前期患者糖代谢异常对慢性牙周炎的影响。方法121例糖尿病前期合并慢性牙周炎患者,根据2007美国疾病控制和预防中心与美国牙周病学会制定的慢性牙周炎诊断标准分为轻度慢性牙周炎组(57例)与中重度慢性牙周炎组(64例)。使用自制调查量表,比较不同程度牙周炎患者年龄、性别、身体质量指数(BMI)、吸烟、饮酒、每天刷牙次数等一般资料及糖代谢指标,分析糖尿病前期患者慢性牙周炎的相关因素。结果轻度牙周炎组吸烟人数占比22.81%显著低于中重度牙周炎组的40.63%,空腹血糖(FBG)(6.28±0.56)mmol/L及糖化血红蛋白(HbA1c)(6.75±1.02)%水平均低于中重度牙周炎组的(7.85±0.74)mmol/L、(8.14±1.21)%,差异均具有统计学意义(P<0.05)。Logistic回归分析结果显示,高水平FBG与高水平HbA1c为糖尿病前期患者慢性牙周炎的危险因素(P<0.05)。结论糖尿病前期患者的糖代谢水平与慢性牙周炎的严重程度密切相关,临床上应给予高度重视。

Objective To investigate the effect of abnormal glucose metabolism on chronic periodontitis in prediabtetic patients.Methods A total of 121 patients with prediabetes and chronic periodontitis were divided into mild chronic periodontitis group(57 cases)and moderate to severe chronic periodontitis group(64 cases)according to the diagnostic criteria for chronic periodontitis established by the American Centers for Disease Control and Prevention and the American Society of Periodontitis in 2007.A self-made questionnaire was used to compare the general data of age,gender,body mass index(BMI),smoking,drinking,daily tooth brushing and glucose metabolism indicators among patients with different degrees of periodontitis.Results The proportion of smokers 22.81% of mild chronic periodontitis group was significantly lower than 40.63% of moderate to severe chronic periodontitis group,and fasting blood glucose(FBG)(6.28±0.56)mmol/L and glycosylated hemoglobin(HbA1c)(6.75±1.02)% were lower than(7.85±0.74)mmol/L and(8.14±1.21)% of moderate to severe chronic periodontitis group.All the difference was statistically significant(P<0.05).Logistic regression analysis showed that high levels of FBG and high levels of HbA1c were risk factors for chronic periodontitis in patients with prediabetes(P<0.05).Conclusion The glycometabolism level in patients with prediabetes is closely related to the severity of chronic periodontitis,and great attention should be paid to it.