4例磷酸盐尿性间叶性肿瘤的临床病理分析

Clinicopathological analysis of 4 cases of phosphateuria mesenchymal tumors

为探讨磷酸盐尿性间叶性肿瘤(PMT)的临床病理学特征。对4例发生于骨的磷酸盐尿性间叶性肿瘤患者的临床资料进行分析,并观察其组织病理学和免疫组化标记。其肿瘤细胞梭形,呈束状或编织状排列,细胞核圆形或卵圆形,无明显核分裂;间质内可见黏液样组织、软骨、骨样基质及成熟脂肪组织,血管丰富,且伴有不规则钙盐沉积;免疫组化:CK(-)Vimentin(+)CD68(+)S100(+)CD34血管(+)Ki67(+)多少不等。磷酸盐尿性间叶性肿瘤是一种罕见的间叶性肿瘤,诊断依赖于组织病理学、免疫组化标记并结合临床资料才能正确诊断,治疗应予以完整切除。

This paper discusses the clinicopathological characteristics of phosphateuria mesenchymal tumors(PMT).The clinical data of 4 cases of phosphateuria mesenchymal tumors was analyzed,and their histopathological and immunohistochemical markers were observed.Tumor cells were spindle shaped and arranged in bundles or weaves,with round or oval nucleus and no obvious division.Mucoid tissue,cartilage,bone-like matrix and mature adipose tissue were found in the interstitium,which has abundant blood vessels and irregular calcium salt deposition.Immunohistochemistry:CK(-)Vimentin(+)CD68(+)S100(+)CD34(+)Ki67(+)varied in number.Phosphaturic mesenchymal tumor are rare mesenchymal tumors.The diagnosis depends on histopathology,immunohistochemical markers and combines with clinical data.Complete resection should be performed.