高校大学生循环骨钙素水平及其相关因素分析

Analysis of the circulating osteocalcin level and its influential factors in university students

目的分析高校大学生循环骨钙素水平及其与选择的钙调节激素、骨及糖脂代谢指标之间的相关性。方法通过问卷调查和血液指标检测,从某大学筛选出103名符合试验要求的非体育专业在校大学生。将受试者按照性别分为男性组和女性组,采用简单和多重线性回归分析两组受试者血清骨钙素水平的相关因素。结果男大学生血清骨钙素水平显著高于女大学生。Pearson相关分析结果表明,男大学生血清骨钙素水平与年龄和体质量指数(body mass index,BMI)呈负相关,而与血清甲状旁腺激素(parathyroid hormone,PTH)和碱性磷酸酶(alkaline phosphatase,ALP)水平呈正相关。经身体形态学指标校正后,与胰岛素水平和稳态模型评估胰岛素抵抗指数呈正相关;女大学生血清骨钙素水平与体重和BMI呈负相关,而与血清PTH、ALP、磷和空腹血糖(fasting blood glucose,FBG)水平呈正相关。经身体形态学指标校正后,与血清25羟维生素D [25-hydroxyvitamine D,25(OH) D]、钙、高密度脂蛋白胆固醇和FBG水平呈正相关。多重线性回归分析进一步表明,男大学生血清骨钙素水平与年龄和BMI独立负相关,而与血清PTH水平独立正相关;女大学生血清骨钙素水平与FBG水平独立正相关。结论高校大学生循环骨钙素水平及其与年龄、BMI、PTH和FBG水平的独立相关性具有性别差异。

Objective The aim of this study was to analyze the association of the circulating osteocalcin levels,with selected calciotropic hormones as well as biochemical markers of the bone,glucose,and lipid metabolism in university students.Methods One hundred and three subjects were recruited from a university and participated in this study.They were divided into two groups according to the gender of the subjects.Univariate linear regression and multiple linear regression were used to determine factors associated with serum osteocalcin levels.Results Serum osteocalcin levels were significantly higher in male subjects than in female subjects(P<0.01).The result of univariate linear regression showed that serum osteocalcin levels in male subjects were negatively correlated with age and BMI,but were positively correlated with serum parathyroid hormone(PTH)and alkaline phosphatase(ALP)levels.After adjustment for basic parameters,serum osteocalcin levels were positively correlated with serum insulin and homeostasis model assessment of insulin resistance(HOMA-IR).Serum osteocalcin levels in female subjects were negatively correlated with body weight and BMI,but were positively correlated with serum PTH,ALP,P,and fasting blood glucose(FBG)levels.After adjustment for basic parameters,serum osteocalcin levels were positively correlated with serum 25(OH)D,calcium,HDL-C,and FBG levels.Multiple linear regression result showed that serum osteocalcin levels in male subjects had independent negative association with age and BMI,and independent positive association with serum PTH level.In female subjects,serum osteocalcin levels had independent positive association with FBG level.Conclusion The circulating osteocalcin level and its independent associations with age,BMI,PTH and FBG levels are gender-dependent in university students.