多塞平联合四联疗法对HP相关慢性胃炎合并抑郁患者的临床疗效观察

Clinical efficacy of doxepin combined with quadruple therapy in patients with HP-related chronic gastritis and depression

目的探讨多塞平联合四联疗法对幽门螺杆菌(HP)相关慢性胃炎合并抑郁患者的临床疗效观察。方法选取我院2017年3月~2020年3月收治的80例HP相关慢性胃炎合并抑郁患者为研究对象,按随机数字表法将研究对象随机分为观察组和对照组,,每组各40例。对照组患者给予四联疗法治疗,观察组在对照组基础上联合多塞平治疗。观察比较两组患者临床疗效、负面情绪、胃肠激素、炎性因子水平、HP阴性率及不良反应发生率。结果观察组患者临床总有效率为90.00%高于对照组的67.50%(P<0.05);治疗后观察组患者的HAMD和HAMA评分低于对照组(P<0.05);治疗后观察组患者血清GAS、CRP、IL-6水平低于对照组,血清SS水平高于对照组(P<0.05);观察组患者的HP阴性率为95.00%高于对照组的75.00%(χ^(2)=4.8039,P<0.05);两组患者的不良反应发生率比较差异无统计学意义(χ^(2)=0.2632,P>0.05)。结论多塞平联合四联疗法可有效改善HP相关慢性胃炎合并抑郁患者的胃肠激素水平,调节炎性因子指标,改善患者腹部不适、腹胀等症状,进一步缓解患者负面情绪,提高HP阴性率,临床疗效确定,安全性较高。

Objective To explore the clinical efficacy of doxepin combined with quadruple therapy in patients with helicobacter pylori(HP)related chronic gastritis and depression.Methods A total of 80 patients with HP-related chronic gastritis and depression admitted to our hospital from March 2017 to March 2020 were retrospectively selected as study subjects,and randomly divided into two groups:the control group(40 cases)was treated with quadruple therapy,and the observation group(40 cases)was treated with doxepin based on the control group.The clinical efficacy,negative emotions,gastrointestinal hormones,inflammatory factors,HP negative rate and adverse reaction rate between the two groups were compared.Results The total effective rate in the observation group was 90.00%higher than that in the control group(67.50%)(P<0.05).After treatment,Hamilton depression scale(HAMD)and Hamilton anxiety scale(HAMA)scores in the observation group were lower than those in the control group(P<0.05).After treatment,the serum levels of gastrin(GAS),C-reactive protein(CRP)and interleukin6(IL-6)in the observation group were lower than those in the control group,and the serum levels of somatostatin(SS)were higher than those in the control group(P<0.05).The HP negative rate in the observation group was 95.00%higher than that in the control group(χ^(2)=4.8039,P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(χ^(2)=0.2632,P>0.05).Conclusion Doxepin combined with quadruple therapy can effectively improve gastrointestinal hormone levels in patients with HP-related chronic gastritis and depression,regulate inflammatory factor indicators,improve symptoms such as abdominal discomfort and abdominal distension,further relieve their negative emotions,improve HP negative rate,and have confirm clinical efficacy and a high safety.