慢性阻塞性肺疾病患者应用乌司他丁治疗的疗效评定分析

Evaluation and analysis of the efficacy of ulinastatin in the treatment of patients with chronic obstructive pulmonary disease

目的:分析应用乌司他丁治疗慢性阻塞性肺疾病(以下简称"慢阻肺")的疗效。方法:2018年4月-2020年4月收治慢阻肺患者78例,奇偶数方式分为两组,各39例。对照组采用常规治疗;观察组联合乌司他丁治疗。比较两组临床疗效、肺功能及炎性指标水平。结果:观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05);观察组治疗后第1秒用力呼吸量(FEV_(1))、FEV_(1)预计值和FEV_(1)和用力呼吸量比值(FEV_(1)/FVC)等肺功能指标水平均高于对照组,差异有统计学意义(P<0.05);观察组治疗后C反应蛋白(CRP)、白介素-8(IL-8)、肿瘤因子-α(TNF-α)等血清炎性因子水平均低于对照组,差异有统计学意义(P<0.05)。结论:应用乌司他丁治疗慢阻肺,患者肺功能和炎性反应改善,疗效比较理想。

Objective:To analyze the efficacy of ulinastatin in the treatment of chronic obstructive pulmonary disease(COPD).Methods:From April 2018 to April 2020,78 patients with COPD were selected,they were divided into the two groups with 39 patients in each group by odd and even number method.The control group was treated with routine treatment.The observation group combined with ulinastatin treatment.The clinical efficacy,pulmonary function and inflammatory indexes were compared between the two groups.Results:The total effective rate in the observation group was significantly higher than that in the control group,the difference was statistically significant(P<0.05).The levels of pulmonary function indexes such as FEV_(1),FEV_(1) expected value and FEV_(1)/FVC in the observation group were significantly higher than those in the control group,the difference was statistically significant(P<0.05).The levels of serum inflammatory factors such as CRP,IL-8 and TNF-αin the observation group were lower than those in the control group after treatment,the difference was statistically significant(P<0.05).Conclusion:Ulinastatin can improve the pulmonary function and inflammatory reaction of patients with chronic obstructive pulmonary disease,and the curative effect is ideal.