不同剂量阿托伐他汀钙治疗老年不稳定型心绞痛并高脂血症患者的治疗效果分析

Analysis of the therapeutic effect of different doses of atorvastatin calcium in the treatment of elderly patients with unstable angina pectoris and hyperlipidemia

目的:探讨不同剂量阿托伐他汀钙治疗老年不稳定型心绞痛并高脂血症患者的临床疗效差异。方法:2018年1月-2020年12月收治老年不稳定型心绞痛并高脂血症患者2500例,随机分为两组,各1250例。两组均口服阿司匹林、血管紧张素转换酶抑制剂、硝酸酯类等药物;对照组加服阿托伐他汀钙10 mg/d;观察组加服阿托伐他汀钙20 mg/d,比较两组治疗效果。结果:观察组治疗后缺血总负荷、2ST和心绞痛发作次数、总胆固醇水平、甘油三酯、低密度脂蛋白胆固醇水平均明显低于与对照组,高密度脂蛋白胆固醇水平高于对照组,差异有统计学意义(P<0.05);观察组心绞痛症状总有效率高于对照组,差异有统计学意义(P<0.05)。结论:高剂量阿托伐他汀钙可以明显降低老年不稳定型心绞痛并高脂血症患者的24 h缺血总负荷、2ST和心绞痛发作次数、总胆固醇、甘油三酯、低密度脂蛋白胆固醇水平,提高高密度脂蛋白胆固醇水平和心绞痛症状总有效率,20 mg/d的高剂量阿托伐他汀钙可以推荐应用。

Objective:To explore the difference in clinical efficacy of different doses of atorvastatin calcium in the treatment of elderly patients with unstable angina pectoris and hyperlipidemia.Methods:From January 2018 to December 2020,2500 elderly patients with unstable angina and hyperlipidemia were selected,they were randomly divided into the two groups with 1250 cases in each group.Both groups were given oral aspirin,angiotensin-converting enzyme inhibitors,nitrates and other drugs.The control group was given atorvastatin calcium 10 mg/d.The observation group was given atorvastatin calcium 20 mg/d.The treatment effect of the two groups were compared.Results:After treatment,the total ischemic load,2 ST and the number of angina pectoris,total cholesterol levels,triacylglycerol and low-density lipoprotein cholesterol levels in the observation group were significantly lower than those in the control group,and the high-density lipoprotein cholesterol levels were higher than those in the control group.the differences were statistically significant(P<0.05).The total effective rate of angina pectoris in the observation group was higher than that of the control group,the difference was statistically significant(P<0.05).Conclusion:High-dose atorvastatin calcium can significantly reduce the 24-hour total ischemic load,2 ST,the number of angina attacks,total cholesterol,triacylglycerol,and low-density lipoprotein cholesterol in elderly patients with unstable angina and hyperlipidemia.It can increase the high-density lipoprotein cholesterol level and the total effective rate of angina pectoris symptoms,high-dose atorvastatin calcium of 20 mg/d can be recommended.