血清EGF YKL-40 SAA水平与帕金森病患者认知障碍的相关性分析

Correlation Analysis of Serum EGF YKL-40 SAA Levels and Cognitive Impairment of Patients with Parkinson's Disease

目的:探究帕金森病(Parkinson’s disease,PD)患者血清人软骨糖蛋白39(YKL-40)、表皮生长因子(epidermal growth factor,EGF)、淀粉样蛋白A(SAA)水平与其认知障碍的关系。方法:选取我院2019年5月至2020年5月期间收治的62例PD患者作为观察组,另选取60例同期体检健康对象作为对照组。分析观察组和对照组的血清YKL-40、EGF、SAA水平,蒙特利尔认知评估量表(MoCA)评分,并记录观察组患者帕金森病统一评分量表(UPDRS)评分,采用Pearson分析UPDRS评分、MoCA评分与PD患者血清YKL-40、EGF、SAA水平的相关性。结果:观察组血清YKL-40、EGF、SAA水平均显著高于对照组,MoCA评分显著低于对照组二者比较具有统计学差异(P<0.05)。记录观察组患者病情病况,其中UPDRSⅠ(3.84±0.47)分,UPDRSⅡ(23.83±3.07)分,UPDRSⅢ(29.9±3.49)分。采用Pearson分析UPDRS评分、MoCA评分与PD患者血清YKL-40、EGF、SAA水平的相关性,结果显示,血清YKL-40、EGF、SAA水平与MoCA评分呈负相关(r=-0.425、-0.548、-0.455,P<0.01),与UPDRSⅠ(r=0.604、0.645、0.592,P<0.01)、UPDRSⅡ(r=0.559、0.527、0.636,P<0.01)、UPDRSⅢ(r=0.584、0.709、0.613,P<0.01)评分均呈正相关。结论:PD患者的血清YKL-40、EGF、SAA水平均明显升高,并与患者的病情和认知障碍存在密切联系,指标水平对临床及早发现和治疗具有一定参考价值。

Objective:To explore the correlation between the level of serum human cartilage glycoprotein 39(YKL-40),epidermal growth factor(EGF),amyloid A(SAA)and cognitive impairment of patients with Parkinson's disease(PD).Methods:A total of 62 PD patients admitted to our hospital from May 2019 to May 2020 were selected as the observation group,and 60 healthy controls during the same period for physical examination were selected as the control group.Analyze the serum YKL-40,EGF,and SAA levels of the observation group and the control group,the Montreal Cognitive Assessment Scale(MoCA)score,and record the observation group’s Parkinson’s disease unified score scale(UPDRS)score.Pearson was used to analyze the correlation between UPDRS score,MoCA score and serum YKL-40,EGF,SAA levels in PD patients.Results:The serum YKL-40,EGF and SAA levels of the observation group were significantly higher than those of the control group,and the MoCA score was significantly lower than that of the control group.There was a statistical difference between the two groups(P<0.05).The condition of patients in the observation group was recorded,including UPDRSⅠ(3.84±0.47)points,UPDRSⅡ(23.83±3.07)points,and UPDRSⅢ(29.9±3.49)points.Pearson was used to analyze the correlation between UPDRS score,MoCA score and serum YKL-40,EGF,SAA levels in PD patients,and the results showed that serum YKL-40、EGF,SAA levels were negatively correlated with MoCA score(r=-0.425,-0.548,-0.455,P<0.01),and UPDRSⅠ(r=0.604,0.645,0.592,P<0.01),UPDRSⅡ(r=0.559,0.527,0.636,P<0.01),UPDRSⅢ(r=0.584,0.709,0.613,P<0.01)0.01).The scores were positively correlated.Conclusion:The levels of serum YKL-40,EGF and SAA in PD patients are significantly increased,and are closely related to the patient's condition and cognitive impairment.The index levels have certain reference value for clinical early detection and treatment.