急性心肌梗死并心力衰竭的老年患者血清中microRNAs与血管内皮细胞功能的相关性

Correlation Between MicroRNAs of Serum and Endothelial Cell Function in Elderly Patients with Acute Myocardial Infarction and Heart Failure

目的:探讨急性心肌梗死并心力衰竭的老年患者血清中microRNAs与血管内皮细胞功能的相关性。方法:自2018年1月至2020年12月,回顾性收集我院收治的急性心肌梗死并心力衰竭的老年患者56例作为观察组,同期收集我院收治的单纯心肌梗死患者93例作为对照组。检测两组患者血清中miRNA-145、miRNA-19b、miRNA-96水平,同时分析血清中miRNA-145、miRNA-19b、miRNA-96与血管内皮细胞功能的相关性。结果:与对照组比较,观察组miRNA-145显著升高(1.76±0.32 vs 1.04±0.31,P<0.001);miRNA-19b显著升高(1.52±0.44 vs 1.08±0.37,P<0.001);miRNA-96显著升高(2.76±0.54 vs 1.43±0.62,P<0.001)。Pearson线性相关性显示miRNA-145、miRNA-19b、miRNA-96与FMD、NO、左心室射血分数显著负相关,与ET-1和NT-pro BNP显著正相关(P<0.05)。结论:miRNA-145、miRNA-19b、miRNA-96在急性心肌梗死并心力衰竭患者中明显升高,且与患者血管内皮细胞功能有关。

Objective:To investigate the correlation between serum microRNAs and vascular endothelial cell function in elderly patients with acute myocardial infarction and heart failure.Methods:From January 2018 to December 2020,56 elderly patients with acute myocardial infarction and heart failure in our hospital were retrospectively collected as an observation group,while 93 patients with simple myocardial infarction in our hospital were collected as a control group.The serum levels of miRNA-145,miRNA-19b and miRNA-96 were detected,and the correlation between serum miRNA-145,miRNA-19b and miRNA-96 and vascular endothelial cell function were analyzed.Results:Compared with the control group,miRNA-145,miRNA-19b and miRNA-96 in the observation group were significantly increased(1.76±0.32 vs 1.04±0.31,P<0.001,1.52±0.44 vs 1.08±0.37,P<0.001,2.76±0.54 vs 1.43±0.62,P<0.001,respectively).Pearson linear correlation showed that miRNA-145,miRNA-19b and miRNA-96 were negatively correlated with FMD,NO and LVEF,and positively correlated with ET-1 and NT-Pro BNP(P<0.05).Conclusion:The miRNA-145,miRNA-19b and miRNA-96 are significantly increased in patients with acute myocardial infarction and heart failure,and are related to the function of vascular endothelial cells.