浙江省德清县农村成年男性饮酒与2型糖尿病发病风险的前瞻性研究

Association of alcohol drinking with the incident risk of type 2 diabetes among rural adult males in Deqing County,Zhejiang Province:a prospective cohort study

【目的】研究男性饮酒与2型糖尿病发病风险的关联性,为早期防治糖尿病提供客观依据。【方法】选取浙江省德清县农村社区基线未患糖尿病的成年男性为研究对象。研究设计为前瞻性队列研究,采用问卷调查、体格检查、实验室测量与电子档案随访的方法统计相关数据,采用Cox多因素回归模型探索男性不同饮酒特征与2型糖尿病发病之间的关系。【结果】本研究平均随访(7.15±2.90)年,新发2型糖尿病病例354例,发病密度为4.15(/千人·年)。在调整协变量后,与不饮酒人群相比,饮酒频率≥7次/周和单次酒精摄入量0.1~19.9 g/次的男性2型糖尿病发病风险均降低,HR(95%CI)值分别为0.72(0.56~0.94)和0.54(0.30~0.99);男性饮酒3~6次/周且单次酒精摄入量≥40.0 g/次者2型糖尿病的发病风险增高,饮酒频率≥7次/周且单次酒精摄入量0~39.9 g/次者2型糖尿病发病风险降低,HR(95%CI)值分别为1.53(1.02~2.30)和0.52(0.28~0.99)。【结论】德清县农村男性居民的不同饮酒模式会影响2型糖尿病的发病风险,进一步深入研究对糖尿病防治工作具有一定理论和现实意义。

[Objective]To investigate the association of alcohol drinking and the incident risk of type 2 diabetes in men and to provide evidences for early prevention of diabetes.[Methods]Rural adult males without diabetes in Deqing County,Zhejiang Province were enrolled.A dynamic prospective cohort study was conducted.Data were collected through questionnaires,physical examination,experimental measurements and a electronic follow-up database.Cox multivariate regression was performed to assess the association of alcohol drinking and the incident risk of type 2 diabetes in men.[Results]During the follow-up period(7.15±2.90 years),354 men developed diabetes,and the incidence rate was 4.15/1000 person-years.After adjusting for confounding factors,the incident risk of type 2 diabetes among the men with high alcohol drinking frequency(≥7 times/week)and low single alcohol intake(0.1-19.9 g/occasion)was lower than that among non-alcohol drinkers,and the value of HR(95%CI)was 0.72(0.56-0.94)and 0.54(0.30-0.99),respectively.Consumption of≥40.0 g alcohol per occasion 3-6 times a week increased the incidence of type 2 diabetes,and consumption of<40.0 g alcohol per occasion over 7 times a week decreased the incidence of type 2 diabetes,with the value of HR(95%CI)of 1.53(1.02-2.30)and 0.52(0.28-0.99)respectively.[Conclusion]Different alcohol drinking patterns affect the incident risk of type 2 diabetes among rural adult males in Deqing County.Further study on alcohol drinking and diabetes may have ethical and practical significance for the prevention and control of diabetes in rural China.