间充质干细胞治疗终末期肝病的研究进展

Advances in the study of mesenchymal stem cells for end-stage liver disease

终末期肝病指各种慢性肝脏损伤所致的肝病晚期阶段,原位肝移植是最主要的最终治疗方案,但目前肝移植仍受许多因素限制。间充质干细胞作为一类具有自我更新能力的多系祖细胞,具有多向分化、抗凋亡、抗炎、免疫抑制等功能。干细胞移植疗法作为终末期肝病的一种潜在治疗方法普遍受到关注。现就间充质干细胞治疗在终末期肝病中应用的研究进展进行综述。

End-stage liver disease refers to the advanced stage of liver disease caused by various chronic liver damage.Orthotopic liver transplantation is the most important final treatment option,but liver transplantation is still limited by many factors at present.Stem cell transplantation therapy has attracted widespread attention as a potential treatment for end-stage liver disease.This article reviews the research progress of mesenchymal stem cell therapy in end-stage liver disease.