持续气道正压通气治疗新生儿呼吸衰竭的效果

Effects of continuous positive airway pressure in treatment of neonatal respiratory failure

目的:观察持续气道正压通气(CPAP)治疗新生儿呼吸衰竭的效果。方法:选取100例呼吸衰竭患儿作为研究对象,按随机数字表法将其分为对照组和研究组各50例。对照组给予常频机械通气(CMV)治疗,研究组给予鼻塞式CPAP治疗,比较两组患儿NICU住院时间、呼吸支持通气时间、治疗前后血清心肌肌钙蛋白(cTnI)水平、N末端脑钠肽(NT-proBNP)水平、血气分析指标水平及并发症发生率。结果:研究组NICU住院时间和呼吸支持通气时间均短于对照组,差异有统计学意义(P<0.05);治疗后,研究组cTnI和NT-proBNP水平均低于对照组,差异有统计学意义(P<0.05);研究组动脉血二氧化碳分压低于对照组,动脉血氧分压高于对照组,差异均有统计学意义(P<0.05);研究组并发症发生率低于对照组,差异有统计学意义(P<0.05)。结论:CPAP治疗呼吸衰竭患儿可缩短NICU住院时间和呼吸支持通气时间,降低cTnI、NT-proBNP水平和并发症发生率,以及改善血气分析指标水平,其效果优于常频机械通气治疗。

Objective:To explore effects of continuous positive airway pressure(CPAP)in treatment of neonatal respiratory failure.Methods:100 cases of neonatal respiratory failure were selected as the research objects,and were divided into control group and study group according to the random number table method,each with 50 cases.The control group was given conventional mechanical ventilation(CMV)treatment,while the study group was given nasal CPAP treatment.The NICU hospitalization time,respiratory support ventilation time,serum cardiac troponin(cTnI)level,N-terminal brain natriuretic peptide(NT-proBNP)level,blood gas analysis index levels,and complication rate were compared between the two groups.Results:The NICU hospitalization time and respiratory support time in the study group were shorter than those in the control group,and the differences were statistically significant(P<0.05).The cTnI and NT-proBNP level of the study group were lower than those of the control group,and the differences were statistically significant(P<0.05).The arterial partial pressure of carbon dioxide in the study group was lower than that of the control group;the arterial partial pressure of oxygen was higher than that of the control group;the differences were statistically significant(P<0.05).Further,the incidence of complications in the study group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusions:CPAP in the treatment of neonatal respiratory failure can shorten the NICU hospitalization time and the respiratory support time,reduce the cTnI level,the NT-proBNP level and the incidence of complications,and improve the blood gas index levels.Moreover,it is superior to conventional mechanical ventilation treatment.