血浆D-二聚体、纤维蛋白原、血小板指标水平检测在后循环短暂性脑缺血发作患者发生脑梗死中的预测价值

Predictive value of plasma D-dimer,fibrinogen and platelet index levels in occurrence of cerebral infarction in patients with posterior circulation transient ischemic attack

目的:观察血浆D-二聚体、纤维蛋白原(FIB)、血小板指标[平均血小板体积(MPV)、血小板计数(PLT)、血小板分布宽度(PDW)和血小板压积(PCT)]水平检测在后循环短暂性脑缺血发作(TIA)患者发生脑梗死中的预测价值。方法:回顾性分析2019年1月至2021年1月该院收治的84例后循环TIA患者的临床资料,按是否继发脑梗死分为TIA组46例和脑梗死组38例。比较两组入院次日血浆D-二聚体、FIB、MPV、PLT、PDW和PCT水平,采用受试者工作特征(ROC)曲线评价各指标对后循环TIA患者发生脑梗死的预测价值。结果:TIA组血浆D-二聚体、FIB、MPV、PLT和PDW水平显著低于脑梗死组,差异有统计学意义(P<0.05);两组PCT水平比较,差异无统计学意义(P>0.05);血浆D-二聚体、FIB、MPV、PLT和PDW预测后循环TIA患者发生脑梗死的ROC曲线下面积分别为0.875、0.975、0.753、0.890、0.856。结论:开展血浆D-二聚体、FIB、MPV、PLT和PDW水平检测对后循环TIA患者发生脑梗死具有较高的预测价值。

Objective:To explore predictive value of plasma D-dimer,fibrinogen(FIB)and platelet index[mean platelet volume(MPV),platelet count(PLT),platelet distribution width(PDW)and platelet packed volume(PCT)]levels in occurrence of cerebral infarction in patients with posterior circulation transient ischemic attack(TIA).Methods:The clinical data of 84 patients with posterior circulation TIA were retrospectively analyzed.According to whether secondary cerebral infarction occurred or not,they were divided into TIA group(46 cases)and cerebral infarction group(38 cases).The plasma levels of D-dimer,FIB,MPV,PLT,PDW and PCT were compared between the two groups on the day after admission.The Receiver operating characteristic(ROC)curve was used to evaluate the predictive value of each index in the occurrence of cerebral infarction in these patients with posterior circulation TIA.Results:The plasma levels of D-dimer,FIB,MPV,PLT and PDW in the TIA group were significantly lower than those in the cerebral infarction group,and the differences were statistically significant(P<0.05).There was no statistically significant difference in the PCT level between the two groups(P>0.05).The area under the ROC curve of the plasma D-dimer,FIB,MPV,PLT and PDW in the prediction of cerebral infarction in the posterior circulation TIA patients were 0.875,0.975,0.753,0.890,0.856,separately.Conclusions:The detection of the levels of plasma D-dimer,FIB,MPV,PLT and PDW has a high predictive value for the occurrence of cerebral infarction in the patients with posterior circulation TIA.