薄氏腹针治疗虚证晚期非小细胞肺癌患者的疗效及免疫调节作用的临床观察

Clinical Observation of Therapeutic Effect and Immune Reulation of Bo’s Abdominal Acupuncture for Advanced Non-Small Cell Lung Cancer Patients with Deficiency Syndrome

【目的】观察薄氏腹针治疗虚证晚期非小细胞肺癌患者的临床疗效及其对免疫功能方面的影响。【方法】将60例虚证晚期非小细胞肺癌患者随机分为观察组和对照组,每组各30例。对照组给予常规药物治疗,观察组在对照组治疗的基础上,给予薄氏腹针针刺治疗,每天1次,7 d为1个疗程,2组均治疗2个疗程。治疗后及随访,观察2组患者的无进展生存时间(PFS)、中位生存时间(MST)和1年生存率,比较2组患者治疗前后1个月T淋巴细胞亚群CD3^(+)T细胞绝对计数、CD4^(+)T细胞绝对计数及CD4^(+)T细胞/CD8^(+)T细胞比值(CD4^(+)/CD8^(+)比值)的变化情况。【结果】(1)截至最后随访日期,观察组的PFS为6.90个月,对照组为5.15个月,观察组的无进展生存时间较对照组明显提升,差异有统计学意义(P<0.05)。(2)观察组的MST为15.56个月,对照组为11.07个月,观察组的中位生存时间较对照组明显提升,差异有统计学意义(P<0.05)。(3)观察组1年生存率为73.33%(22/30),对照组1年生存率为53.33%(16/30),观察组1年生存率明显优于对照组(P<0.05)。(4)治疗后,2组患者的CD3^(+)T细胞绝对计数、CD4^(+)T细胞绝对计数及CD4^(+)/CD8^(+)比值均明显改善(P<0.05),且观察组在改善CD3^(+)T细胞绝对计数、CD4^(+)T细胞绝对计数及CD4^(+)/CD8^(+)比值方面明显优于对照组,差异有统计学意义(P<0.05)。【结论】薄氏腹针可通过“引气归元”等补益方法改善虚证晚期非小细胞肺癌患者的生存期及生活质量,并且能够提高患者的免疫功能,具有较好的临床疗效。

Objective To observe the clinical curative effect of Bo’s abdominal acupuncture on advanced nonsmall cell lung cancer patients with deficiency syndrome and its influence on immune function.Methods Sixty cases of advanced non-small cell lung cancer patients were randomly divided into observation group and control group,30 cases in each group.The two groups were treated with routine medicines,in addition,the observation group was treated with Bo’s abdominal acupuncture,once a day,7 days constituted one course,the treatment covering 2 courses.After treatment and during follow-up,progression-free survival(PFS)time,median survival time(MST),and one-year survival rate of the two groups were observed.Before and one month after treatment,the changes of absolute count of T lymphocyte subsets CD3^(+)T-lymphocytes,CD4^(+)T-lymphocytes and ratio of CD4^(+)to CD8^(+)T-lymphocytes(CD4^(+)/CD8^(+)ratio)were compared between the two groups.Results(1)Until the last follow-up date,PFS time was 6.90 months in the observation group,and 5.15 months in the control group.The PFS time in the observation group was longer than that in the control group,the difference being significant(P<0.05).(2)Until the last follow-up date,MST was 15.56 months in the observation group,and 11.07 months in the control group.The MST in the observation group was longer than that in the control group,the difference being significant(P<0.05).(3)Until the last follow-up date,one-year survival rate was 73.33%(22/30)in the observation group,and 53.33%(16/30)in the control group.The one-year survival rate in the observation group was longer than that in the control group,the difference being significant(P<0.05).(4)After treatment,the absolute count of CD3^(+)T-lymphocytes,CD4^(+)T-lymphocytes cells and CD4^(+)/CD8^(+)ratio of the two groups were improved,and the improvement in absolute count of CD3^(+)T-lymphocytes,CD4^(+)T-lymphocytes and CD4^(+)/CD8^(+)ratioof the observation group was superior to that of the control group,the difference being significant(P<0.05).Conclusion Bo’s abdominal acupuncture is effective for improving the survival time and quality of life of patients with advanced non-small cell lung cancer of deficiency syndrome by the replenishing therapy such as“conducting qi back to its source”,and can improve the immune function of the patients.