加减黄连阿胶汤联合耳穴压豆治疗糖尿病合并失眠患者的临床观察

Clinical Observation of Modified Huanglian Ejiao Decoction Combined with Ear Acupoint Seed-Pressing for Treatment of Diabetes Mellitus Patients with Insomnia

【目的】观察加减黄连阿胶汤联合耳穴压豆治疗糖尿病合并失眠的临床疗效。【方法】将68例糖尿病合并失眠患者随机分为治疗组和对照组,每组各34例。2组患者均给予基础降糖治疗及健康宣教的常规处理。对照组在常规处理方案的基础上,给予艾司唑仑片口服,治疗组在对照组治疗的基础上,给予加减黄连阿胶汤联合耳穴压豆治疗。2组均治疗30 d,治疗30 d后,观察2组患者治疗前后中医证候总积分、匹兹堡睡眠质量指数(PSQI)评分的变化情况,并比较2组患者空腹血糖(FPG)、餐后2 h血糖(PPG)的变化情况。【结果】(1)治疗后,2组患者的中医证候总积分明显改善(P<0.01),且观察组在改善中医证候总积分方面明显优于对照组,差异有统计学意义(P<0.01)。(2)治疗后,2组患者的PSQI评分明显改善(P<0.01),且观察组在改善PSQI评分方面明显优于对照组,差异有统计学意义(P<0.01)。(3)治疗后,2组患者的FPG与PPG含量均明显改善(P<0.01),且观察组在改善FPG与PPG含量方面明显优于对照组,差异有统计学意义(P<0.05或P<0.01)。【结论】加减黄连阿胶汤联合耳穴压豆治疗糖尿病合并失眠患者,能明显改善患者的临床症状,从而提高患者的生活质量,疗效显著。

Objective To observe the clinical efficacy of modified Huanglian Ejiao Decoction combined with ear acupoint seed-pressing for the treatment of diabetes mellitus with insomnia. Methods Sixty-eight diabetes mellitus patients with insomnia were randomly divided into treatment group and control group,34 cases in each group. Both groups of patients received basic hypoglycemic treatment and health care,in addition,the control group received oral use of estazolam tablets,and the treatment group received modified Huanglian Ejiao Decoction combined with ear acupoint seed-pressing on the basis of the treatment of the control group. Both groups were treated for 30 days.After 30 days of treatment, the changes of total score of traditional Chinese medicine(TCM) syndromes,Pittsburgh Sleep Quality Index(PSQI)score,and levels of fasting plasm glucose(FPG)and 2-hour postprandial plasm glucose(PPG)were observed in the two groups before and after treatment. Results(1)After treatment,the total scores of TCM syndromes of the two groups were significantly improved(P < 0.01),and the improvement in total scores of TCM syndromes of the treatment group was significantly superior to that of the control group(P <0.01).(2)After treatment,the PSQI scores of the two groups were significantly improved(P < 0.01),and the improvement in PSQI scores of the treatment group was significantly superior to that of the control group(P <0.01).(3)After treatment,the FPG and PPG contents of the two groups were significantly improved(P < 0.01),and the improvement in FPG and PPG contents of the treatment group was significantly superior to that of the control group(P < 0.05 or P < 0.01). Conclusion Modified Huanglian Ejiao Decoction combined with ear acupoint seed-pressing is effective for improving the symptoms of the diabetes mellitus patients with insomnia, thus improves the quality of life of the patients.