SPECT在下肢动脉疾病中的应用及进展

Application and progress of SPECT in patients with lower extremity artery disease

下肢动脉疾病(LEAD)指下肢动脉慢性进行性粥样硬化过程,继发下肢疼痛、间歇性跛行、难愈性溃疡等,降低患者生存质量,甚者危及生命。SPECT可定量评估下肢血流灌注,灵敏度高,在LEAD早期诊断、病情评估、治疗方案制定及疗效评估中具有一定优势。放射性核素标记的分子靶向显像剂可直接显示缺血诱导的血管新生过程。该文就SPECT在LEAD中的应用及进展进行综述。

Lower extremity artery disease(LEAD)is a progressive atherosclerotic process that results in progressive limb ischemia leading to life-altering claudication,nonhealing ulcers,limb amputation,which reduces the patient′s quality of life and even threatens life.SPECT can provide noninvasive quantitative evaluation of lower extremity blood perfusion with high sensitivity,and has advantages on patient management,such as early detection,severity evaluation,treatment protocol development and therapeutic effect monitoring.Moreover,radionuclide-labeled molecular targeting imaging agents can directly show ischemia-induced angiogenesis.This article reviews the application and progress of SPECT in LEAD.