乳腺癌芳香化酶抑制剂相关关节疼痛中西医诊疗进展

Progress of Diagnosis and Treatment on Aromatase Inhibitor-induced Arthralgia in Breast Cancer

乳腺癌绝经后激素受体阳性患者常采用芳香化酶抑制剂作为内分泌治疗的药物,而关节疼痛是其主要的不良反应。文章从中西医角度总结相关文献,按诊断标准、病因学研究、中医病因病机、中西医治疗现状对乳腺癌芳香化酶抑制剂相关关节疼痛进行概述,提出当前研究存在的问题,西医目前针对此不良反应尚无系统的诊疗方案,发病机制仍有待探索,且治疗方法存在不良反应明显或临床疗效需进一步证实等问题,而中医疗法近年来显示出较好的疗效,该文从中药、中成药、针灸疗法三部分归类整理中医治疗手段,研究发现,虽然中医疗法具有独特优势,但临床运用尚不广泛,中药、中成药的疗效缺乏高质量、多中心的随机对照临床研究加以验证。今后仍需进一步明确病因、发病机制,探索中西医治疗方案,推动临床系统诊疗的进展。

Patients with breast cancer who postmenopausal hormone receptor are positive often take aromatase inhibitors as endocrine therapy,and arthralgia is the most adverse effect.This article was reviewed from the perspective of traditional Chinese and Western medicine and was summarized by the diagnostic criteria,etiology research,etiology and pathogenesis of traditional Chinese medicine and treatment of traditional Chinese and Western medicine.This article found that there was no systematic diagnosis and treatment guideline for this adverse effect in Western medicine.And the pathogenesis remains to be explored.There are side effects from the treatment in Western medicine and the clinical efficacy needs to be further confirmed.In recent years,traditional Chinese medicine has shown better effects.This article classified from Chinese herbal medicine,Chinese patent medicine and acupuncture and moxibustion therapy.And found that although traditional Chinese medicine has unique advantages,it is not widely used in clinical practice,and the efficacy was lacked of high-quality,multi-center and random trials.In the future,it is still necessary to further clarify the etiology and pathogenesis,explore the appropriate treatment of traditional Chinese and Western medicine,and promote the progress of clinical systematic diagnosis and treatment.