119例胸腺瘤临床特征分析

Clinical characteristics of 119 thymomas

目的研究胸腺瘤发病年龄、肿瘤大小、Ki-67阳性率、CYFRA21-1、中性粒细胞与淋巴细胞计数比值(NLR)、中性粒细胞、淋巴细胞、嗜酸性粒细胞计数与胸腺瘤WHO分型、Masaoka分期的关系,以便更好地判断肿瘤恶性程度,进一步指导治疗。方法回顾性分析2014年12月-2020年9月徐州医科大学附属医院确诊的119例胸腺瘤患者临床资料,分析发病年龄、肿瘤大小、Ki-67阳性率、CYFRA21-1、NLR、中性粒细胞、淋巴细胞、嗜酸性粒细胞计数与胸腺瘤WHO分型(良、恶性)、Masaoka分期(早、晚期)的关系。结果胸腺瘤WHO分型(良、恶性)在Masaoka分期(早、晚期)中分布的差异无统计学意义(P> 0.05);不同性别在发病年龄、肿瘤大小、Ki-67阳性率、CYFRA21-1、WHO分型(良、恶性)、Masaoka分期(早、晚期)中比较差异无统计学意义(P>0.05);发病年龄和Ki-67阳性率在良、恶性胸腺瘤中比较差异有统计学意义(P <0.05);肿瘤大小及CYFRA21-1在早、晚期胸腺瘤中比较差异有统计学意义(P <0.05)。结论性别不是决定胸腺瘤临床特征的因素,通过检测Ki-67阳性率及CYFRA21-1可评估胸腺瘤的恶性程度。

Objective To investigate the relationship between the onset age of thymoma,tumor size,Ki-67 positive rate,CYFRA21-1,neutrophil to lymphocyte count ratio(NLR),neutrophil,lymphocyte,eosinophil counts and thymoma WHO pathological type and Masaoka stage,so as to better determine the malignancy of thymoma and guide further treatment.Methods A total of 119 patients with thymoma who were diagnosed in the Affiliated Hospital of Xuzhou Medical University from December 2014 to September 2020 were enrolled and their clinical data were retrospectively analyzed.The relationship between the onset age of thymoma,tumor size,Ki-67 positive rate,CYFRA21-1,NLR,neutrophil,lymphocyte,eosinophil counts and thymoma WHO pathological type(benign and malignant)and Masaoka stage(early and advanced)were analyzed.Results The distribution of WHO pathological type(benign and malignant)in Masaoka stage(early and advanced)was not statistically different(P>0.05).There was no statistical difference between male and female in the onset age of thymoma,tumor size,Ki-67 positive rate,CYFRA21-1,WHO pathological type(benign and malignant)and Masaoka stage(early and advanced)(P>0.05).The onset age and the positive rate of Ki-67 were significantly different in benign and malignant thymoma(P<0.05).Tumor size and CYFRA21-1 were significantly different between early and advanced thymoma(P<0.05).Conclusions Sex is not the factor that determines the clinical characteristics of thymoma.The malignancy of thymoma can be assessed through measurement of the positive rate of Ki-67 and CYFRA21-1.