日本乙型脑炎病毒E蛋白毒力相关氨基酸位点的研究进展

Research progress on the virulence-related amino acid sites of Japanese encephalitis virus E protein

日本乙型脑炎是由日本乙型脑炎病毒(JEV)引起的一种虫媒性、人兽共患急性流行性传染病。该病毒通过入侵人、猪、马和野生动物的脑神经引起病毒性脑炎,对人和动物造成严重的危害。E蛋白是JEV的毒力蛋白,E蛋白某些毒力氨基酸位点突变会改变JEV的致病性,这些位点通常被作为检测弱毒疫苗质量关键监测目标和判断野毒JEV变异毒力强弱的依据。本文对JEV E蛋白毒力相关氨基酸位点的研究进展进行综述,为研究JEV减毒分子机制和预防JEV变异提供理论基础。

Japanese encephalitis is a kind of vector-borne,zoonotic acute infectious disease caused by Japanese encephalitis virus(JEV).The virus causes viral encephalitis by invading the brain nerves of humans,pigs,horses and wild animals,it is harmful to humans and animals.E protein is the virulence protein of JEV.Come virulence amino acid site mutations of E protein can change the pathogenicity of JEV.These sites are usually used as key targets for detecting the quality of attenuated vaccines and judging the virulence of wild virus JEV mutations.Basis This article reviews the research progress of the virulence-related amino acid sites of JEV E protein,and provides a theoretical basis for studying the molecular mechanism of JEV attenuation and preventing JEV mutation.