脂质代谢重编程与肝癌代谢应激

Lipid Metabolic Reprogramming and Metabolic Stress in Liver Cancer

近期研究表明,肝癌所处的微环境对其生长和转移等过程有重要的调控作用。代谢重编程是肝癌细胞在缺糖、缺氧微环境造成的代谢应激状态下的适应性代谢改变,其中脂质代谢重编程是一个重要的组成部分。既往研究揭示了部分在肝癌细胞中代谢模式发生改变的脂质类型,同时在一定程度上阐明了这些脂质代谢重编程过程的生物学功能和调控机制。然而,目前仍有许多脂质代谢重编程过程没有得到深入解析,对其在肝癌发生发展过程中的作用和机制仍知之甚少。另外,如何通过靶向脂质代谢重编程中的关键调控因子达到治疗肝癌的目的,目前仍是转化医学研究的一大挑战。本文介绍了肝癌细胞中脂质的来源、脂质代谢重编程的主要功能,以及驱动脂质代谢重编程的因素,有望为未来通过调节或限制肝癌细胞脂质代谢重编程来治疗肝癌提供理论依据和潜在的候选靶点。

Recent studies have shown that tumor microenvironment plays an important regulatory role in the growth and metastasis of liver cancer.Metabolic reprogramming represents a series of adaptive metabolic alterations that liver cancer cells undertake when they are under metabolic stress caused by glucose deficiency and hypoxia microenvironment,and lipid reprogramming is an important part of it.Previous studies have revealed a variety of lipid types with altered metabolic patterns in liver cancer cells,and have,to a certain extent,investigated the biological functions and regulatory mechanisms of these lipid metabolic reprogramming processes.However,there are still many lipid metabolic reprogramming processes that have not received thorough investigation,and little is known about their roles and mechanisms in the pathogenesis and development of liver cancer.In addition,how to accomplish the goal of treating liver cancer by targeting key regulatory factors in lipid metabolic reprogramming still remains a major challenge in translational medical research.This paper introduced the sources of lipids and the main functions and driving factors of lipid metabolic reprogramming in liver cancer cells,attempting to provide a theoretical basis and potential therapeutic targets for the treatment of liver cancer through regulating or restricting lipid metabolic reprogramming.