氟比洛芬酯与地佐辛静脉自控镇痛持续用药在剖宫产术后镇痛中的效果比较

Comparation on the Effect of Continuous Medication of Flurbiprofen Axetil and Dezocine Patient-Controlled Intravenous Analgesia after Cesarean Section

目的比较氟比洛芬酯与地佐辛静脉自控镇痛(PCIA)持续用药在剖宫产术后镇痛中的效果。方法将2018年9月至2020年3月在我院行剖宫产术的78例产妇随机分为A组(单纯舒芬太尼PCIA持续用药)、B组(氟比洛芬酯联合舒芬太尼PCIA持续用药)、C组(地佐辛联合舒芬太尼PCIA持续用药),各26例。三组产妇均镇痛至术后48 h。比较三组产妇术后镇痛48 h期间镇痛泵按压次数、术后48 h及术后首次下床活动时的VAS评分。结果术后镇痛48 h期间,C组平均镇痛泵按压次数少于A组与B组,B组平均镇痛泵按压次数少于A组(P<0.05)。术后48 h及术后首次下床活动时,B组与C组的VAS评分均低于A组,且C组的VAS评分低于B组(P<0.05)。结论与氟比洛芬酯相比,剖宫产术后采用地佐辛PCIA持续用药的效果更好,可减少镇痛过程中加药次数,减轻产妇术后疼痛。

Objective To compare the effect of continuous medication of flurbiprofen axetil and dezocine patient-controlled intravenous analgesia(PCIA)after cesarean section.Methods 78 puerperae undergoing cesarean section in our hospital from September 2018 to March 2020 were randomly divided into group A(continuous medication of sufentanil PCIA alone),group B(continuous medication of flurbiprofen axetil combined with sufentanil PCIA)and group C(continuous medication of dezocine combined with sufentanil PCIA),with 26 cases in each group.All puerperae were given analgesic until 48 hours after operation.The analgesic pump compression times during postoperative 48-hour analgesia,and the VAS scores at 48 hours after operation and the first out-of-bed time after operation were compared among the three groups.Results During postoperative 48-hour analgesia,the average times of analgesic pump compression in group C were fewer than those in group A and group B,and the average times of analgesic pump compression in group B were fewer than those in group A(P<0.05).At 48 hours after operation and the first out-of-bed time after operation,the VAS scores in group B and group C were lower than those in group A,and the VAS scores in group C were lower than those in group B(P<0.05).Conclusions Compared with flurbiprofen axetil,continuous medication of dezocine PCIA after cesarean section has better effect,which can reduce the dosing times during analgesia,and reduce postoperative pain of puerperae.