亚甲基四氢叶酸还原酶基因多态性对妊娠结局的影响

Impact of of Methylenetetrahydrofolate Reductase Gene Polymorphism on the Pregnancy Outcome

目的探讨亚甲基四氢叶酸还原酶(MTHFR)基因多态性对妊娠结局的影响。方法从有流产史或畸形胎儿史妇女中筛选出MTHFR 6771298基因突变的高风险人群70名作为研究对象,随机分为两组各35例。对照组给予叶酸800μg/d,实验组给予活性三代叶酸800μg/d,比较两组C677T位点的基因分布情况和妊娠结局。结果C677T位点的基因分布中,实验组的CC占比显著高于对照组,CT占比显著低于对照组(P<0.05)。实验组的流产、妊高征、抑郁、胎儿畸形发生率分别为2.86%、17.14%、8.57%、5.71%,均显著低于对照组的17.14%、40.00%、28.57%、22.86%(P<0.05)。结论MTHFR基因多态性会对妊娠结局产生影响,必须重视孕期叶酸的补给,以减少不良妊娠结局。

Objective To explore the impact of methylenetetrahydrofolate reductase(MTHFR)gene polymorphism on the pregnancy outcome.Methods 70 high-risk cases with MTHFR 6771298 gene mutation were selected from women with history of abortion or history of fetal malformation,and were randomly divided into two groups,with 35 cases in each group.The control group was given folic acid 800μg/d,and the experimental group was given active third generation folic acid 800μg/d.The gene distribution of C677T site and the pregnancy outcome were compared between two groups.Results In the gene distribution of C677T site,the proportion of CC in the experimental group was significantly higher than that in the control group,and the proportion of CT was significantly lower than that in the control group(P<0.05).The incidences of abortion,pregnancy induced hypertension,depression and fetal malformation in the experimental group were 2.86%,17.14%,8.57%and 5.71%respectively,significantly lower than 17.14%,40.00%,28.57%and 22.86%in the control group,respectively(P<0.05).Conclusions MTHFR gene polymorphism can affect the pregnancy outcome.Attention must be paid to folic acid supplementation during pregnancy to reduce adverse pregnancy outcome.