阿替普酶注射剂联合瑞舒伐他汀钙片治疗急性脑梗死的临床研究

Clinical Study of Alteplase Injection Combined with Rosuvastatin Calcium Tablet in the Treatment of Acute Cerebral Infarction

目的探讨阿替普酶注射剂联合瑞舒伐他汀钙片治疗急性脑梗死的临床效果。方法68例急性脑梗死患者随机分为两组各34例,对照组给予瑞舒伐他汀钙片治疗,研究组给予阿替普酶注射剂联合瑞舒伐他汀钙片治疗,比较两组的疗效和不良反应。结果治疗后,研究组的hs-CRP、IL-1β、TNF-α、总胆固醇、甘油三酯、低密度脂蛋白水平均显著低于对照组(P<0.05)。研究组的总有效率显著高于对照组,不良反应发生率显著低于对照组(P<0.05)。结论阿替普酶注射剂联合瑞舒伐他汀钙片治疗急性脑梗死能有效改善患者的血脂水平,降低炎性因子水平,治疗安全性较高。

Objective To explore the clinical effect of alteplase injection combined with rosuvastatin calcium tablet in the treatment of acute cerebral infarction.Methods 68 patients with acute cerebral infarction were randomly divided into two groups,with 34 cases in each group.The control group was treated with rosuvastatin calcium tablet,while the study group was treated with alteplase injection combined with rosuvastatin calcium tablet.The efficacy and adverse reaction were compared between two groups.Results After treatment,the levels of hs-CRP,IL-1β,TNF-α,total cholesterol,triglyceride and low density lipoprotein of the study group were significantly lower than those of the control group(P<0.05).The total effective rate of the study group was significantly higher than that of the control group,and the incidence of adverse reactions was significantly lower than that of the control group(P<0.05).Conclusions Alteplase injection combined with rosuvastatin calcium tablet in the treatment of acute cerebral infarction can effectively improve the levels of blood lipids and reduce the levels of inflammatory factors of patients,with high treatment safety.