无效食管运动在胃食管反流病中作用的研究进展

Research advances on the role of ineffective esophageal motility in gastroesophageal reflux disease

胃食管反流病(GERD)是临床上常见的消化道动力障碍性疾病,而食管动力状态的异常是其主要发病机制之一。无效食管运动(IEM)是GERD中最常见的食管动力障碍类型,但其在GERD发病机制中的作用仍存在争议。本文就近年来IEM的病理生理学、临床特点、动力学特征及与酸暴露的关系、以及在GERD中的作用研究进展进行总结,旨在为指导临床诊断和治疗GERD提供新的思路。

Gastroesophageal reflux disease(GERD)is a clinically common gastrointestinal motility disorder,and esophageal motility disorder is one of its main pathogenesis.Ineffective esophageal motility(IEM)is the most common type of esophageal motility disorder in GERD.The role of IEM in the pathogenesis of GERD is still controversial.This article summarizes the pathophysiology,clinical features,dynamic characteristics and relationship with acid exposure of IEM,and its role in GERD.It provides new ideas and clues for further research on the role of IEM and guiding clinical treatment of GERD.