质子泵抑制剂治疗胃食管反流病的研究进展

Research progress of proton pump inhibitors in the treatment of gastroesophageal reflux disease

胃食管反流病(GERD)是消化系统最常见疾病之一,其发病机制及临床表现复杂多样,临床治愈率低、复发率高,严重影响患者生心健康,加重家庭经济负担及社会医疗资源的耗费,是消化系统疾病中较为顽固的治疗难题之一。GERD的治疗包括心理及生活方式干预、标准药物治疗、内镜和必要时的外科手术治疗等,但目前药物治疗仍是首选。质子泵抑制剂(PPI)是目前临床应用最广、疗效较好的一类强抑酸药,本文就PPI在GERD中的研究进展做一综述。

Gastroesophageal reflux disease(GERD)is one of the most common diseases of the digestive system.Its pathogenesis and clinical manifestations are complex and diverse,with a low clinical cure rate and a high recurrence rate,which seriously affect the quality of patients'health and increase family finances Burden and consumption of social medical resources are one of the more stubborn treatment problems in digestive system diseases.The treatment of GERD includes psychological and lifestyle intervention,standard medical treatment,endoscopy and surgical treatment if necessary,but drug treatment is still the first choice.Proton Pump Inhibitors(PPI)are currently the most widely used clinically effective class of strong acid inhibitors.This article reviews the research progress of PPI in GERD.