厄多司坦辅助PAP治疗OSAHS的疗效及安全性观察

Effect and Safety of Erdosteine-assisted PAP in the Treatment of Obstructive Sleep Apnea Hypopnea Syndrome

目的:观察厄多司坦辅助气道正压通气(PAP)治疗阻塞性睡眠呼吸暂停低通气综合征(OSAHS)的疗效及安全性。方法:选取2019年4月至2021年1月上海交通大学医学院附属第九人民医院黄浦分院收治的OSAHS患者64例作为研究对象,随机分成对照组和观察组,每组32例。对照组予以PAP治疗,观察组在此基础上口服厄多司坦治疗。连续治疗5周后,评估2组患者的临床疗效,比较治疗前后2组患者夜间最低血氧饱和度(LSaO_(2))、呼吸暂停通气指数(AHI)以及血清中γ-干扰素(IFN-γ)及白细胞介素-4(IL-4)水平。记录治疗过程中2组患者出现的不良反应。结果:治疗5周后观察组治疗有效率高于对照组(P<0.05)。2组患者LSaO_(2)较治疗前均有升高,且观察组高于对照组(P<0.05),AHI较治疗前均有降低,且观察组低于对照组(P<0.05)。观察组患者血清IFN-γ较治疗前降低,且低于对照组,对照组血清IFN-γ较治疗前升高(P<0.05),2组患者血清IL-4较治疗前均无明显改变(P>0.05)。治疗过程中2组患者均未出现严重不良反应(P>0.05)。结论:厄多司坦辅助PAP治疗OSAHS疗效显著,能有效改善患者通气功能,同时可调节机体内细胞因子水平以控制炎症反应,且安全性高。

Objective:To observe the effect and safety of erdosteine-assisted positive airway pressure(PAP)in the treatment of obstructive sleep apnea hypopnea syndrome(OSAHS).Methods:From April 2019 to January 2021,64 OSAHS patients admitted to the Huangpu Branch of 9th People′s Hospital were enrolled as the research objects.They were randomly divided into observation and control group,32 cases each.The control group was treated with PAP,while observation group was additionally treated with oral erdosteine.After 5 weeks of continuous treatment,clinical curative effect of both groups was evaluated.The levels of lowest oxygen saturation at night(LSaO_(2)),apnea hypopnea index(AHI),serum interferon-γ(IFN-γ)and interleukin(IL)-4 before and after treatment were compared between the two groups.The adverse reactions during treatment in both groups were recorded.Results:After 5 weeks of treatment,the response rate of treatment in observation group was higher than that in control group(P<0.05).After 5 weeks of treatment,LSaO_(2) in both groups was increased,which was higher in observation group than control group.AHI was decreased,which was lower in observation group than control group(P<0.05).After treatment,level of serum IFN-γin observation group was decreased,lower than that in control group.And level of serum IFN-γin control group was higher than that before treatment(P<0.05).There was no significant change in serum IL-4 before and after treatment in either group(P>0.05).During treatment,there were no serious adverse reactions in either group(P>0.05).Conclusion:The curative effect of erdosteine-assisted PAP is significant on OSAHS,which can effectively improve ventilation function of patients,and regulate cytokines to control inflammatory response with high safety.