经鼻持续气道正压通气联合高压氧疗法对重症OSAHS患者血气指标及睡眠质量的影响

Effect of Nasal Continuous Positive Airway Pressure Combined with Hyperbaric Oxygen Therapy on Blood Electrolyte Indicators and Sleep Quality in Severe OSAHS Patients

目的:探讨经鼻持续气道正压通气(NCPAP)联合高压氧疗法(Hyper Baric Oxygen,HBO)对重症阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者血气指标及睡眠质量的影响。方法:选取2018年3月至2020年9月青岛市即墨区中医医院收治的OSAHS患者60例作为研究对象,随机分为对照组和观察组,每组30例。2组均给予NCPAP治疗,观察组另给予HBO疗法。观察2组治疗前及治疗4周后血气指标动脉血氧分压(PaO_(2))、动脉血氧饱和度(SaO_(2))、pH值,睡眠状态指标睡眠紊乱指数(AHI)、睡眠效率(SE)、微觉醒指数(MAI)及睡眠质量指标匹兹堡睡眠质量指数(PSQI)的变化。结果:治疗4周后2组PaO_(2)、SaO_(2)、pH值、SE均较治疗前显著上升,且观察组较对照组升高更明显(P<0.05);2组AHI、MAI及PSQI评分均较治疗前显著下降,且观察组明显低于对照组(P<0.05)。结论:NCPAP联合HBO可明显纠正OSAHS患者夜间缺氧情况,提高其睡眠质量,对患者预后恢复有利。

Objective:To investigate the effect of nasal continuous positive airway pressure(NCPAP)combined with hyperbaric oxygen therapy(HBO)on blood electrolyte indicators and sleep quality in patients with severe obstructive sleep apnea hypopnea syndrome(OSAHS).Methods:From March 2018 to September 2020,60 OSAHS patients in Jimo District TCM Hospital were selected and randomly divided into control and observation group,with 30 cases each.Both groups were treated with NCPAP,and observation group was additionally treated with HBO.The blood electrolyte indicators[arterial partial pressure of blood oxygen(PaO_(2)),arterial blood oxygen saturation(SaO_(2)),pH value],sleep status[apnea-hypopnea index(AHI),sleep efficiency(SE),micro-arousal index(MAI)]and sleep quality[Pittsburgh Sleep Quality Index(PSQI)]were observed in the two groups before and after 4w of treatment.Results:After 4w of treatment,the PaO_(2),SaO_(2),pH and SE in the two groups were increased significantly compared with those before treatment,and the increases in observation group were more significant than those in control group(P<0.05).The AHI,MAI and PSQI score in the two groups were significantly decreased compared to before treatment,and the above indicators in observation group were significantly lower than those in control group(P<0.05).Conclusion:NCPAP combined with HBO can significantly improve the nocturnal hypoxia and the sleep quality in OSAHS patients,which is beneficial to prognosis.