温胆汤加减治疗失眠症疗效及对PSQI评分影响的Meta分析

Meta-analysis of Modified Wendan Decoction in Treating Insomnia

目的:评价温胆汤加减治疗失眠症的疗效、安全性及对匹兹堡睡眠质量指数(PSQI)评分的影响。方法:通过网络检索国家知识基础设施数据库(CNKI)、中国学术期刊数据库(CSPD)、中文科技期刊数据库(CCD)中截止到2021年4月发表的所有关于温胆汤加减治疗失眠症的随机对照试验,由2名研究者独立筛选文献并进行质量评价以及数据提取,然后运用RevMan5.4软件进行Meta分析。结果:共纳入18篇文献,研究对象共1582例,其中观察组804例,对照组778例。Meta分析结果显示温胆汤加减治疗失眠症与口服镇静催眠药比较,可提高总有效率、降低不良反应发生率、降低PSQI量表总分及睡眠质量、入睡时间、睡眠效率、日间功能的因子评分。结论:温胆汤加减与口服镇静催眠药比较,可以提高临床治疗效果、改善患者临床症状,且具有更高的安全性。

Objective:To evaluate the efficacy and safety of modified Wendan Decoction in the treatment of insomnia and its influence on PSQI scores.Methods:All randomized controlled trials on Wendan decoction in the treatment of insomnia published up to April 2021 in Wanfang,CNKI and VIP database were searched online.Two researchers independently conducted quality evaluation and data extraction.Meta-analysis was performed with RevMan5.4 software.Results:A total of 18 papers were included,containing 1582 subjects,804 in the observation group and 778 in the control group.Meta-analysis results showed that compared with oral sedative hypnotics,Wendan Decoction in the treatment of insomnia can improve the total effective rate,reduce the incidence of adverse reactions,and reduce the scores of PSQI scale,sleep quality,sleep duration,sleep efficiency and daytime function factor scores.Conclusion:Compared with oral sedative hypnotics,modified Wendan Decoction can improve the treatment effect and clinical symptoms of patients with higher safety.