洛美沙星联合红霉素对支气管肺炎患者的治疗效果及对炎症反应的影响

Effects of Lomefloxacin Combined with Erythromycin on the Curative Effects and Inflammatory Reaction of Patients with Bronchial Pneumonia

目的探讨洛美沙星联合红霉素对支气管肺炎的治疗效果及对炎症反应的影响。方法选取2019年5月至2020年9月在长沙市中心医院接受诊治的支气管肺炎患者100例作为研究对象,按照随机数字表法分为红霉素组与联合用药组,各50例。两组患者给予常规治疗,红霉素组在常规治疗的基础上给予患者静脉滴注红霉素,联合用药组在红霉素组基础上静脉滴注洛美沙星。比较两组患者血清炎症介质水平、临床症状消失时间和临床治疗效果。结果两组患者治疗前肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)及白细胞介素-8(IL-8)水平比较差异无统计学意义(P>0.05),联合用药组治疗后TNF-α(12.27±3.56)ng/L、hs-CRP(0.86±0.21)mg/L及IL-8(15.74±5.01)ng/L低于红霉素组(P<0.05)。联合用药组治疗后痰鸣音或啰音消失时间(5.94±1.21)d、憋喘消失时间(2.37±0.68)d、咳嗽消失时间(5.32±1.25)d短于红霉素组(P<0.05)。联合用药组患者治疗有效率96.00%高于红霉素组72.00%(P<0.05)。结论洛美沙星联合红霉素对支气管肺炎患者治疗效果显著,可缩短临床康复时间,改善患者炎症反应。

Objective To explore the therapeutic effects of lomefloxacin combined with erythromycin on bronchial pneumonia and its influence on inflammatory reaction.Methods A total of 100 patients with bronchopneumonia admitted to Changsha Central Hospital from May 2019 to September 2020 were selected as the research objects.According to the random number method,they were assigned into an erythromycin group and a combination group,with 50 cases in each group.Both groups were given conventional treatment;the erythromycin group was given intravenous drip of erythromycin on the basis of conventional treatment;the combined medication group was given intravenous drip of lomefloxacin on the basis of erythromycin group.The levels of serum inflammatory factors,the disappearance time of clinical symptoms and the clinical treatment effect of the 2 groups were compared.Results There was no significant difference in the levels of TNF-α,hs-CRP and IL-8 between the 2 groups before treatment(P>0.05).After treatment,the levels of TNF-α(12.27±3.56)pg/mL,hs-CRP(0.86±0.21)mg/L and IL-8(15.74±5.01)pg/mL in the combination group were lower than those in the erythromycin group(P<0.05).The disappearance time of sputum sounds or rales(5.94±1.21)days,suffocation disappearance time(2.37±0.68)days and disappearance time of cough(5.32±1.25)days in combination group were lower than those in erythromycin group(P<0.05).The total effective rate in the combination group was 96.00% higher than that in the erythromycin group 72.00%(P<0.05).Conclusion Lomefloxacin combined with erythromycin in the treatment of patients with bronchial pneumonia has significant curative effect.It can shorten the clinical recovery time,and improve the inflammatory reaction of patients.