系统性红斑狼疮患者的血清ACA检测结果分析

Analysis of serum ACA test results in patients with systemic lupus erythematosus

目的:分析系统性红斑狼疮(SLE)患者的血清抗心磷脂抗体结果,在继发性抗磷脂综合征的临床诊断价值。方法:2018年7月-2020年8月收治SLE患者148例(SLE组),选取同期健康体检者100例(对照组)。采用酶联免疫吸附法检测ANA、抗-dsDNA抗体、抗ENA抗体、ACA,并进行结果分析。结果:SLE组三种抗体联合检测阳性率高于对照组,差异有统计学意义(P<0.05);且SLE组单项抗ANA、抗dsDNA、抗ENA抗体的阳性率均高于对照组,差异有统计学意义(P<0.05)。SLE组ACA阳性率高于对照组,差异有统计学意义(P<0.05)。结论:SLE患者的血清ACA检测,在继发性抗磷脂综合征的诊断、病情监测及预后评估方面具有重要意义。

Objective:To analyze the results of serum anticardiolipin antibodies in patients with systemic lupus erythematosus(SLE),and its clinical diagnostic value in secondary antiphospholipid syndrome.Methods:From July 2018 to August 2020,148 patients with SLE(the SLE group)were selected.100 healthy patients(the control group)were selected during the same period.Enzyme-linked immunosorbent assay was used to detect ANA,anti-dsDNA antibody,anti-ENA antibody,ACA,and we analyzed the results.Results:The positive rate of the combined detection of the three antibodies in the SLE group was higher than that in the control group,the difference was statistically significant(P<0.05).And the positive rates of single anti-ANA,anti-dsDNA,and anti-ENA antibodies in the SLE group were higher than those in the control group,the difference was statistically significant(P<0.05).The positive rate of ACA in the SLE group was higher than that in the control group,the difference was statistically significant(P<0.05).Conclusion:The detection of serum ACA in patients with systemic lupus erythematosus is of great significance in the diagnosis,condition monitoring and prognosis evaluation of secondary antiphospholipid syndrome.