神经胶质细胞在脑铁代谢中的作用

Role of Neuroglia Cell in Cerebral Iron Metabolism

铁是人体中最丰富的微量元素之一,参与细胞的许多生理活动和生命代谢过程。特定大脑区域的铁沉积可能是导致神经退行性疾病的原因,且过量的铁与细胞中的过氧化氢通过芬顿反应产生高活性自由基,引起细胞过氧化损伤和继发引起细胞毒性,加重组织损伤。因此脑铁代谢紊乱可能是导致神经系统疾病的原因之一。神经胶质细胞具有形成血脑屏障、调节神经元代谢、分泌和合成多种细胞因子等作用,并能调控铁离子在大脑中的吸收、储存和释放,在脑内铁稳态调节过程中发挥重要作用,可保护脑内其他细胞免受铁介导的氧化应激损伤。深入研究脑铁代谢可为相关疾病的防治提供新的思路。

Iron(Fe)is one of the most abundant trace elements in the human body,and it participates in many cell physiological activities and metabolic processes of life.The deposition of iron in specific brain regions may lead to neurodegenerative diseases,and excessive iron and H 2O 2 in the cells generate highly active free radicals through the Fenton reaction,leading to cell peroxidation damage and secondary cytotoxicity,aggravating tissue damage.Therefore,brain iron metabolism disorder may be one of the causes of neurological diseases.Glial cells have roles of supporting structure and forming a blood-brain barrier,regulatinge neuronal metabolism,secreting and synthesizing a variety of cytokines,etc.,and can regulate the absorption,accumulation and release of iron ions,in the brain,playing an important role in the regulation of iron homeostasis which can protect other cells in the brain from iron-mediated oxidative stress damage.Understanding brain iron meta-bolism in depth may provide new approaches for the prevention and treatment of related diseases.