Ki-67、p53等免疫指标在上皮性卵巢癌预后判断及化疗敏感性预测中的价值

Value of Immune Indexes Like Ki-67,p53,in Prognosis and Chemosensitivity Prediction of Epithelial Ovarian Cancer

卵巢癌是一种常见的妇科恶性肿瘤,其中绝大多数为上皮性卵巢癌。大部分卵巢癌确诊时已处于疾病晚期,往往预后不良。铂类耐药是晚期或复发性卵巢癌预后不良的重要原因,而合理敏感的化疗方案可提高卵巢癌患者的术后生存率,延长患者生存期。临床上有效、便捷的预测卵巢癌患者预后及化疗敏感性的生物学指标包括Ki-67、p53、雌激素受体、孕激素受体等,其表达水平对判断上皮性卵巢癌患者化疗敏感性及其预后具有预测价值。

Ovarian cancer is a common gynecological malignant tumor,most cases of which are epithelial ovarian cancer.Most ovarian cancers are already in advanced stages at the time of diagnosis,and the prognosis is poor.In addition,platinum agents resistance is an important reason for the poor prognosis of advanced or recurrent ovarian cancer.Reasonable and sensitive chemotherapy can increase the survival rate and prolong the survival time of the patients.Clinically,effective and convenient biological indicators for predicting the prognosis and chemosensitivity of the patients with ovarian cancer include Ki-67,p53,estrogen receptor,and progesterone receptor,etc.,and their expression levels have predictive value for judging the chemosensitivity and prognosis of the patients.