上皮间质营养单元在慢性气道疾病中的研究进展

Research Progress of Epithelial-Mesenchymal Trophic Unit in Chronic Airway Diseases

慢性气道疾病包括哮喘和慢性阻塞性肺疾病(COPD),两者均会导致气道阻塞和气道重塑的改变。近年来,COPD的发病率和病死率不断增加,但目前针对慢性气道疾病进行的选择性治疗疗效欠佳,临床治疗也仅依赖支气管扩张剂和皮质类固醇等药物缓解症状,而不是治疗潜在的发病机制。气道重塑包括气道结构组织和细胞的变化,如气道壁增厚、上皮代谢、杯状细胞肥大以及平滑肌增生等。而上皮间质营养单元(EMTU)作为一个整体参与了慢性气道疾病气道重塑的发生、发展,因此,未来可以通过EMTU的早期改变识别慢性气道疾病的发生,并针对EMTU进行早期干预以控制疾病的发展。

Chronic airway diseases include asthma and chronic obstructive pulmonary disease(COPD),both of which lead to airway obstruction and remodeling.The incidence and mortality of COPD are increasing every year.However,the selective treatment of chronic airway diseases is not effective.The clinical treatments still rely on bronchodilators and corticosteroids to relieve symptoms,rather than treatment targeting the latent pathogenesis.Airway remolding includes changes of airway structure tissue and cells,such as airway wall thickening,epithelial metabolism,goblet cell hypertrophy and smooth muscle hyperplasia.Epithelial-mesenchymal trophic unit(EMTU)as a whole participates in the occurrence and development of airway remodeling in chronic airway diseases.In the future,the occurrence of chronic airway diseases can be identified by early changes of EMTU,and early intervention will be carried out to control the development of the diseases.