脓毒症免疫抑制机制及免疫调理治疗新进展

New Progress in Immunosuppressive Mechanism and Immunomodulation Treatment of Sepsis

脓毒症是机体对感染反应失控而引发的器官功能障碍,具有高发病率、高病死率等特点,是临床重症患者常见的死亡原因之一。脓毒症发病机制复杂,免疫功能紊乱是其发生、发展的中心环节,而免疫抑制与不良结局密切相关。对脓毒症患者进行早期诊断和治疗有助于降低病死率。对脓毒症患者抗炎细胞因子、免疫细胞凋亡、负性共刺激分子等免疫相关指标进行比较及分析,可以为未来脓毒症的免疫调理治疗提供更多的选择,同时有利于患者预后的评估。

Sepsis is an organ dysfunction caused by the body′s out-of-control response to infection.It has the characteristics of high morbidity and mortality,and is one of the common causes of death in critically ill patients in clinics.The pathogenesis of sepsis is complex.Immune dysfunction is the central link in the occurrence and development of sepsis,and immunosuppression is closely related to adverse outcomes.Early diagnosis and treatment of sepsis patients can help to reduce the mortality.By comparing and analyzing the immune-related indicators such as anti-inflammatory cytokines,immune cell apoptosis and negative costimulatory molecules in the patients with sepsis,we can provide more options for the immunomodulation treatment of sepsis in the future,which will also be helpful for the assessment of its prognosis.