细菌性肝脓肿的诊疗研究进展

Research Progress in Diagnosis and Treatment of Pyogenic Liver Abscess

细菌性肝脓肿(PLA)指细菌经多种途径感染肝脏,导致肝内发生炎症、液化、坏死、脓液积聚,从而形成化脓性病灶。近年来因肝脓肿的发病机制、病因、临床表现的改变,其对临床医师的诊治水平提出了新挑战。随着分子诊断技术及免疫学分析在临床中的应用,PLA早期的发现率及临床诊断率不断提高。同时因介入治疗的发展及抗生素的大量使用,PLA的临床诊治也出现了新变化。虽然大部分PLA可通过介入治疗达到痊愈,但近年来随着腹腔镜技术的成熟,其治愈率上升,费用下降。因此,腹腔镜技术对PLA的诊治有着广阔的前景,未来需深入研究。

Pyogenic liver abscess(PLA)is a bacterial infection of the liver through a variety of ways,leading to inflammation,liquefaction,necrosis,pus accumulation in the liver,resulting in the formation of purulent lesions.In recent years,the pathogenesis,etiology and clinical manifestations of liver abscess are constantly changing,which poses new challenges to the diagnosis and treatment of the clinicians.With the application of molecular diagnostic technology and immunological analysis in clinic,the early detection rate and clinical diagnosis rate of PLA are also increasing.At the same time,due to the development of interventional therapy and the extensive use of antibiotics,the clinical diagnosis and treatment of PLA has also undergone new changes.Although most of the PLA can be cured through interventional therapy,in recent years,with the maturity of laparoscopic technology,the cure rate has increased and the cost has decreased.Therefore,laparoscopic technology has a broad prospect for the diagnosis and treatment of PLA,and needs further study in the future.