免疫球蛋白G4与恶性肿瘤

Immunoglobulin G4 and Malignant Tumors

外周血免疫球蛋白G4(immunoglobulin G4,IgG4)异常升高以及病变组织中大量IgG4阳性浆细胞浸润是IgG4相关性疾病(IgG4 related disease,IgG4⁃RD)最显著的临床病理特征。IgG4⁃RD临床表现多样,病变几乎可以累及任何组织/器官,已引起学者们的广泛关注。随着研究的深入,发现IgG4表达异常不仅可引起IgG4⁃RD,作为一种免疫反应负向调控因子,IgG4与恶性肿瘤的发生与预后、肿瘤免疫均有一定相关性。本文回顾了IgG4与恶性肿瘤的关系及其在肿瘤免疫中的作用进展。

Abnormal elevation of serum immunoglobulin G4(IgG4)and abundant infiltration of IgG4⁃positive plasma cells in diseased tissues are the most common clinicopathological features of IgG4⁃related disease(IgG4⁃RD).It can affect almost any tissue and organ,and has a variety of clinical manifestations.In⁃creasing studies have found that as a member of IgG family that negatively regulates immune response,IgG4 is correlated with the occurrence and prognosis of malignant tumors and with tumor immunity.This paper reviewed the relationship between IgG4 and malignant tumors and the role of IgG4 in tumor immunity.