主动脉瓣膜间质细胞分化机制研究进展

Research progress on the differentiation mechanism of aortic valve interstitial cells

瓣膜纤维化或钙化是瓣膜性心脏病(VHD)的两大重要病理表现,其中瓣膜间质细胞(VICs)由成纤维细胞样表型分化为肌成纤维细胞表型或成骨细胞表型,是瓣膜发生早期病理改变的关键环节。VHD多累及主动脉瓣,近年来有关VICs分化的研究多聚焦于主动脉瓣来源细胞。本文就主动脉瓣VICs分化的最新研究进展予以综述,旨在为VHD的防治研究提供更为全面的参考。

Heart valve fibrosis and calcification are two impartant pathological changes of valvular heart diseases(VHD).The differentiation of valve interstitial cells(VICs)from fibroblast like phenotype to myofibroblast like phenotype or osteoblast like phenotype is considered as the milestone event of the early pathological changes of VHD.Aortic valves are the major target organs in VHD development.In recent years,studies on the differentiation of VICs were mainly focused on aortic valve derived cells.In this paper we summarize the recent findings on the differentiation of VICs,aim to provide a comprehensive background for the development of novel prevention and treatment strategies for VHD.