摘要
Parkinson’s Disease(PD),second only to Alzheimer’s disease,is a neurodegenerative disease,most commonly occurring in people over the age of 65 years and is mostly caused by loss of dopamine neurons[1].Clinically,motor symptoms such as resting tremor,motor retardation,muscular rigidity,and disturbance of postural balance are the main symptoms,followed by non-motor symptoms such as cognitive impairment,autonomic nervous system dysfunction,depression,and sleep disorder[2].In 2016,>6.1 million people were affected with PD globally,2.4 times the number in 1990.The large number of affected people,coupled with the high mortality and disability rates,has placed a great burden on society[3].Traditional treatment methods mainly include drugs and surgery and are supplemented by physical therapy.
基金
National Key R&D Program of China(2017YFA0105000)
the National Natural Science Foundation of China(U1904207,81530037,91849115,and 82001973)
the Provincial and Ministry of Health Construction Committee of Henan Province(SBGJ2020003017)
the Excellent Youth Foundation of Henan Health Commission.
